Roles of SDE2 and TIMELESS at active and stalled DNA replication forks.
Roles of SDE2 and TIMELESS at active and stalled DNA replication forks.
复制标题
SDE2 和 TIMELESS 在活跃和停滞的 DNA 复制叉中的作用。
DOI：
10.1080/23723556.2020.1855053
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发表时间：
2021
影响因子：
2.1
通讯作者：
Kim,Hyungjin
中科院分区：
文献类型：
--
作者：
Lo,Natalie;Rageul,Julie;Kim,Hyungjin
叉保护复合体（FPC）由TIMELESS (TIM)-TIPIN异源二聚体组成，作为复制体的支架，支持DNA的无缝复制。我们最近发现，pnas相关的DNA复制应激调节因子SDE2维持FPC的完整性，并与TIM一起保护停滞的复制叉免受核分解降解。
The fork protection complex (FPC), comprising the TIMELESS (TIM)-TIPIN heterodimer, acts as a scaffold of the replisome to support seamless DNA replication. We recently showed that SDE2, a PCNA-associated DNA replication stress regulator, maintains the integrity of the FPC, and together with TIM, protects stalled replication forks from nucleolytic degradation.