The G-protein beta3 subunit 825 TT genotype is associated with epigastric pain syndrome-like dyspepsia.
The G-protein beta3 subunit 825 TT genotype is associated with epigastric pain syndrome-like dyspepsia.
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DOI：
10.1186/1471-2350-11-13
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发表时间：
2010-01-26
影响因子：
--
通讯作者：
Miwa H
中科院分区：
文献类型：
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作者：
Oshima T;Nakajima S;Yokoyama T;Toyoshima F;Sakurai J;Tanaka J;Tomita T;Kim Y;Hori K;Matsumoto T;Miwa H
虽然功能性消化不良（FD）的家族聚类已被报道，但遗传学在FD易感性中的作用仍未得到很好的理解。一些报道表明FD与g蛋白β3 （GNB3）亚基基因多态性（C825T）之间存在关联；然而，这些研究的样本量较小，研究结果尚无定论。在本研究中，我们明确了GNB3基因多态性与每年到医院进行健康检查的大量日本受试者的消化不良之间的关系。排除有明显上消化道病变的受试者。有消化不良症状的受试者根据Rome III标准分为餐后窘迫综合征（PDS）组和上胃痛综合征（EPS）组。然后评估GNB3 C825T多态性的存在，并使用逻辑回归分析对所有变量进行检验。非消化不良组GNB3基因型分布为191 CC（25.1%）、368 TC（48.4%）、202 TT(26.5%)；消化不良组GNB3基因型分布为17 CC（25.0%）、29 TC（42.6%）、22 TT（32.4%）。GNB3 825TT基因型与消化不良无显著相关性。然而，TT基因型与eps样症状的受试者显著相关(优势比(OR) = 2.00, 95%可信区间（CI）；1.07-3.76)，与性别和年龄调整后的CT/CC基因型相比。GNB3多态性与pds样症状无显著相关性（OR = 0.68, 95% CI; 0.31-1.51）。在排除同时出现EPS和pds样症状的受试者后，只有TT基因型与EPS样症状显著相关（OR = 2.73, 95% CI; 1.23-5.91）。纯合子GNB3 825T等位基因影响eps样消化不良的易感性。
Although familial clustering of functional dyspepsia (FD) has been reported, the role of genetics in the susceptibility to FD is still not well understood. Several reports indicate an association between FD and G-protein β3 (GNB3) subunit gene polymorphism (C825T); however, these studies had small sample sizes and the findings are inconclusive. In the present study we clarified the association between GNB3 gene polymorphism and dyspepsia in a large population of Japanese subjects who visited a hospital for annual health check-up. Subjects with significant upper gastrointestinal findings were excluded. Subjects with dyspeptic symptoms were divided into either a postprandial distress syndrome (PDS) group or an epigastric pain syndrome (EPS) group according to the Rome III criteria. The presence of the GNB3 C825T polymorphism was then evaluated and logistic regression analysis was used to test all variables. The GNB3 genotype distribution in subjects without dyspepsia was 191 CC (25.1%), 368 TC (48.4%), and 202 TT (26.5%) and 17 CC (25.0%), 29 TC (42.6%), and 22 TT (32.4%) in subjects with dyspepsia. No significant correlation was found between the GNB3 825TT genotype and dyspepsia. However, the TT genotype was significantly associated with subjects with EPS-like symptoms (odds ratio (OR) = 2.00, 95% confidence interval (CI); 1.07-3.76) compared to the CT/CC genotype adjusted for gender and age. No significant correlation was found between GNB3 polymorphism and PDS-like symptoms (OR = 0.68, 95% CI; 0.31-1.51). With the exclusion of subjects with both EPS- and PDS-like symptoms, only the TT genotype was significantly associated with EPS-like symptoms (OR = 2.73, 95% CI; 1.23-5.91). The homozygous GNB3 825T allele influences the susceptibility to EPS-like dyspepsia.