Increased prevalence of the Heschl's gyrus duplication pattern common to various first-episode psychoses
Increased prevalence of the Heschl's gyrus duplication pattern common to various first-episode psychoses
复制标题
各种首发精神病常见的赫施尔回重复模式的患病率增加
DOI：
10.1016/j.schres.2022.12.020
复制
发表时间：
2023
影响因子：
4.5
通讯作者：
Pantelis Christos
中科院分区：
文献类型：
--
作者：
Takahashi Tsutomu;Sasabayashi Daiki;Wood Stephen J.;McGorry Patrick D.;Suzuki Michio;Velakoulis Dennis;Pantelis Christos
在大约30-50%的健康成年人中检测到的Heschl's gyrus（HG）重复的患病率（Abdul-Kareem和Sluming，2008）在精神分裂症的早期阶段的患者中增加（Takahashi等人，2021 a），表明它是早期神经发育异常的稳定标志物。尽管HG的灰质减少似乎是精神分裂症特有的，而不是其他精神障碍（Takahashi等人，2009），HG回旋化模式的疾病特异性在很大程度上仍未被研究。因为处于发展具有异质结果的精神病的高风险的个体（Fusar-Poli等人，2013）表现出重复HG的患病率增加（Takahashi等人，目的：探讨162例不同类型精神病（FEP）首发患者的HG旋转模式，并与正常对照组比较。（中位病程= 27天）和62名健康对照（表1），使用1.5 T GE Signa扫描仪和3D扰相梯度回波序列获得T1加权磁共振（MR）图像。成像参数为：TR= 14.3 ms，TE= 3.3 ms，FOV= 24× 24 cm，翻转= 30，矩阵= 256× 256，体素尺寸= 0.938× 0.938× 1.5 mm。研究参与者的样本特征在其他地方描述（Takahashi等人，2009年，补充材料）。简而言之，入院前未用药的具有当前精神病症状的患者接受结构化临床访谈（Spitzer等人，1990)-在澳大利亚维多利亚的早期精神病预防和干预中心进行的DSM诊断。46例患者最终被诊断为精神分裂症，57例精神分裂样障碍，34例情感性精神病，25例其他精神病。通过当地广告招募无精神病家族史或病史的健康对照。当地伦理委员会批准了本研究的方案，并获得了所有参与者的书面知情同意书。
The prevalence of the Heschl's gyrus (HG) duplication, detected in approximately 30–50% of healthy adults (Abdul-Kareem and Sluming, 2008), is increased in patients in the early stages of schizophrenia (Takahashi et al., 2021a), indicating that it is a stable marker of early neurodevelopmental anomalies. Although the gray matter reduction of HG appears to be specific to schizophrenia and not other psychotic disorders (Takahashi et al., 2009), the disease specificity of the HG gyrification pattern remains largely unexamined. Because individuals at a high risk of developing psychosis with heterogeneous outcomes (Fusar-Poli et al., 2013) exhibit an increased prevalence of duplicated HG (Takahashi et al., 2021b), the HG pattern may have potential as a general marker for vulnerability to psychosis.To examine HG gyrification patterns in 162 first-episode inpatients with various psychoses (FEP)(median illness duration= 27 days) and 62 healthy controls (Table 1), T1-weighted magnetic resonance (MR) images were obtained using a 1.5 T GE Signa scanner with a 3D spoiled gradient-recalled echo sequence. Imaging parameters were: TR= 14.3 ms, TE= 3.3 ms, FOV= 24× 24 cm, Flip= 30, Matrix= 256× 256, voxel dimension= 0.938× 0.938× 1.5 mm. Sample characteristics of the study participants were described elsewhere (Takahashi et al., 2009, Supplementary material). Briefly, patients with current psychotic symptoms who were unmedicated before admission received Structured Clinical Interview (Spitzer et al., 1990)-based DSM diagnoses at the Early Psychosis Prevention and Intervention Centre, Victoria, Australia. Forty-six patients were eventually diagnosed with schizophrenia, 57 with schizophreniform disorder, 34 with affective psychosis, and 25 with other psychoses. Healthy controls with no family or medical history of psychiatric illness were recruited via local advertisements. The local Ethics Committees approved the protocol of the present study and written informed consent was obtained from all participants.