Influence of the nucleus area distribution on the survival fraction after charged particles broad beam irradiation
Influence of the nucleus area distribution on the survival fraction after charged particles broad beam irradiation
复制标题
带电粒子宽束照射后核面积分布对存活率的影响
DOI：
10.1088/0031-9155/59/15/4197
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
K.J.Kirkby
中科院分区：
文献类型：
--
作者：
A.C.Were;L.Barazzuol;J.C.Jeynes;M.J.Merchant;M.Suzuki;K.J.Kirkby
众所周知，重离子的宽束辐照导致每个细胞接收的命中数的变化，因为粒子的分布遵循泊松统计。虽然细胞核面积将决定给定剂量下接受的命中数，但通常不考虑其辐照细胞群之间的差异。在这项工作中，我们调查的核面积的分布对存活分数的影响。更具体地说，这项工作的目的是解释的偏差，或尾巴，这可能是观察到的存活分数在高辐射剂量。为此，将细胞核面积分布添加到梁泊松统计和线性二次模型中，以拟合实验数据。如本研究所示，细胞核大小的变化，以及相关的泊松统计，可以导致一个向上的生存趋势后，宽束照射。使用正态分布以及线性二次模型参数（α和β）沿着研究分布参数（平均面积和标准差）的影响。最后，本文提出的模型成功地测试了85 keV µm− 1碳离子宽束辐照的LN 18细胞的存活分数，并确定了细胞核区域的分布。
It is well known that broad beam irradiation with heavy ions leads to variation in the number of hit (s) received by each cell as the distribution of particles follows the Poisson statistics. Although the nucleus area will determine the number of hit (s) received for a given dose, variation amongst its irradiated cell population is generally not considered. In this work, we investigate the effect of the nucleus area's distribution on the survival fraction. More specifically, this work aims to explain the deviation, or tail, which might be observed in the survival fraction at high irradiation doses. For this purpose, the nucleus area distribution was added to the beam Poisson statistics and the Linear-Quadratic model in order to fit the experimental data. As shown in this study, nucleus size variation, and the associated Poisson statistics, can lead to an upward survival trend after broad beam irradiation. The influence of the distribution parameters (mean area and standard deviation) was studied using a normal distribution, along with the Linear-Quadratic model parameters (α and β). Finally, the model proposed here was successfully tested to the survival fraction of LN18 cells irradiated with a 85 keV µm− 1 carbon ion broad beam for which the distribution in the area of the nucleus had been determined.