The role of locus coeruleus in the regulation of cognitive performance
The role of locus coeruleus in the regulation of cognitive performance
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DOI：
10.1126/science.283.5401.549
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发表时间：
1999-01-22
期刊：
影响因子：
56.9
通讯作者：
Aston-Jones, G
中科院分区：
文献类型：
--
作者：
Usher, M;Cohen, JD;Aston-Jones, G
实验记录了猴子在视觉识别任务中的去肾上腺素能蓝斑（LC）神经元，并建立了一个计算模型来解释LC脑系统在认知表现中的作用。自发和刺激诱导的LC活动模式的变化与行为表现的波动密切相关。该模型根据LC神经元之间电紧张耦合的变化来解释这些波动，并预测在高耦合和同步LC放电时期的性能改善。同时记录的LC神经元的交叉相关证实了这一预测，表明LC中的电子耦合可能在注意调制和山羊导向与探索行为的调节中发挥重要作用。
Noradrenergic locus coeruleus (LC) neurons were recorded in monkeys performing a visual discrimination task, and a computational model was developed addressing the role of the LC brain system in cognitive performance. Changes in spontaneous and stimulus-induced patterns of LC activity correlated closely with fluctuations in behavioral performance. The model explains these fluctuations in terms of changes in electrotonic coupling among LC neurons and predicts improved performance during epochs of high coupling and synchronized LC firing. Cross correlations of simultaneously recorded LC neurons confirmed this prediction, indicating that electronic coupling in LC may play an important role in attentional modulation and the regulation of goat-directed versus exploratory behaviors.