In vitro adsorption of various pharmaceutical to montmorillonite.
In vitro adsorption of various pharmaceutical to montmorillonite.
复制标题
蒙脱石体外吸附多种药物。
DOI：
10.1002/jps.2600650623
复制
发表时间：
1976
影响因子：
3.8
通讯作者：
J. Lach
中科院分区：
文献类型：
--
作者：
J. Mcginity;J. Lach
溶解和透析研究表明，阳离子药物和某些非离子药物与蒙脱土的结合较强。一个单位粘土所结合的药物的数量变化很大。阴离子药物结合较弱，预计这些药物的生物利用度问题较少。提出了阳离子药物与蒙脱土结合的机理：一个阳离子交换反应，然后是强表面化学吸附。
Dissolution and dialysis studies showed that cationic drugs and certain nonionic drugs bind strongly to montmorillonite clay. The quantity of drug bound by one unit of clay varied considerably. Anionic drugs were weakly bound, and less bioavailabilty problems would be anticipated with these medicinals. The mechanism of binding of cationic drugs to montmorillonite was proposed as a two-step process: a cation-exchange reaction followed by strong surface chemisorption.