The elevated preoperative neutrophil-to-lymphocyte ratio predicts poor prognosis in intrahepatic cholangiocarcinoma patients undergoing hepatectomy
The elevated preoperative neutrophil-to-lymphocyte ratio predicts poor prognosis in intrahepatic cholangiocarcinoma patients undergoing hepatectomy
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术前中性粒细胞与淋巴细胞比率升高预示接受肝切除术的肝内胆管癌患者预后不良。
DOI：
10.1007/s13277-015-3188-6
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发表时间：
2015-07-01
期刊：
影响因子：
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通讯作者：
Dai, Zhi
中科院分区：
文献类型：
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作者：
Chen, Qing;Yang, Liu-Xiao;Dai, Zhi
据报道，术前外周血嗜中性粒细胞与淋巴细胞比率（NLR）高是各种癌症患者生存率低的预测因素。本研究的目的是评估NLR在肝内胆管细胞癌（ICC）肝切除术患者中的预测意义。从2005年至2011年，322例因ICC接受肝切除术的患者入选本回顾性研究。临床病理学参数，包括NLR，进行了评估，以确定肝切除术后的总体和无复发生存的预测因子。NLR的最佳截止值为2.49，322例患者中有177例（54.9%）的NLR >= 2.49。NLR= 2.49的患者肝切除术后5年生存率为51.1%（P=0.0001）。单变量分析显示NLR与无复发生存期（RFS）和总生存期（OS）显著相关（均P
A high preoperative peripheral blood neutrophil-to-lymphocyte ratio (NLR) has been reported to be a predictor of poor survival in patients with various cancers. The aim of this study was to evaluate the predictive significance of the NLR in patients undergoing hepatectomy for intrahepatic cholangiocarcinoma (ICC). From 2005 to 2011, 322 patients who underwent hepatectomy for ICC were enrolled in this retrospective study. Clinicopathological parameters, including NLR, were evaluated to identify predictors of overall and recurrence-free survival after hepatectomy. The best cutoff for NLR was 2.49, and 177 of 322 patients (54.9 %) had an NLR >= 2.49. The 5-year survival rate after hepatectomy was 51.1 % in patients with NLR= 2.49 (P=0.0001). Univariate analyses revealed that NLR was significantly associated with recurrence-free survival (RFS) and overall survival (OS; both P