Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils.
Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils.
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GTS-21（一种新型烟碱受体激动剂）对沙鼠缺血引起的延迟性神经元死亡的保护作用。
DOI：
10.1254/jjp.76.23
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
H. Watanabe
中科院分区：
文献类型：
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作者：
M. Nanri;J. Yamamoto;H. Miyake;H. Watanabe
使用蒙古沙鼠脑缺血模型研究了 GTS-21 [3-(2,4-二甲氧基亚苄基)-新碱二盐酸盐]的神经保护作用，并与尼古丁、9-氨基-1,2,3,4-四氢吖啶盐酸盐水合物 (THA) 和戊巴比妥钠 (PB) 的神经保护作用进行了比较。通过缺血再灌注后 2 天和 3 天的逐步被动回避任务来阐明学习表现和记忆保留。在这项任务中，经过缺血手术的沙鼠表现出学习表现和记忆保留受损。缺血后7天观察到海马CA1区神经元细胞死亡。当腹膜内注射时缺血前30分钟，GTS-21 (5 mg/kg)、(-)-尼古丁(1.5 mg/kg)、THA (5 mg/kg)和PB (50 mg/kg)显着减轻缺血引起的被动回避能力损伤和神经元细胞死亡。当缺血前每天口服两次，持续两周时，GTS-21 (10 mg/kg) 显着抑制健忘症和神经元细胞死亡，而 (-)-尼古丁 (10 mg/kg) 和 THA (10 mg/kg) 仅抑制健忘症。这些结果表明，GTS-21不仅对学习和记忆障碍发挥保护作用，而且对延迟神经元死亡也发挥保护作用，并且GTS-21的潜在机制不同于尼古丁或THA。
The neuroprotective effects of GTS-21 [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride] were studied and compared with those of nicotine, 9-amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate (THA) and pentobarbital-Na (PB) using a cerebral ischemia model in Mongolian gerbils. The learning performance and memory retention were elucidated by a step-through passive avoidance task at 2 and 3 days after ischemia-reperfusion. In this task, the ischemia-operated gerbils showed impairment of learning performance and memory retention. Neuronal cell death in the hippocampal CA1 area was observed at 7 days after ischemia. When administered i.p. 30 min before ischemia, GTS-21 (5 mg/kg), (-)-nicotine (1.5 mg/kg), THA (5 mg/kg) and PB (50 mg/kg) significantly attenuated the impairment of passive avoidance performance and the neuronal cell death induced by the ischemia. When administered orally twice daily for 2 weeks prior to the ischemia, GTS-21 (10 mg/kg) significantly suppressed both amnesia and neuronal cell death, while (-)-nicotine (10 mg/kg) and THA (10 mg/kg) suppressed only the amnesia. These results suggest that GTS-21 exerts a protective activity on not only impairment of learning and memory but also delayed neuronal death and that the underlying mechanism of GTS-21 differs from that of nicotine or THA.
神经化学物质与选择性神经元脆弱性相关。
影响因子：
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作者：
Wieloch,T
通讯作者：
Wieloch,T