Uniform zwitterionic polymer hydrogels with a nonfouling and functionalizable crosslinker using photopolymerization
Uniform zwitterionic polymer hydrogels with a nonfouling and functionalizable crosslinker using photopolymerization
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DOI：
10.1016/j.biomaterials.2011.06.006
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发表时间：
2011-10-01
期刊：
影响因子：
14
通讯作者：
Jiang, Shaoyi
中科院分区：
文献类型：
--
作者：
Carr, Louisa R.;Zhou, Yibo;Jiang, Shaoyi
我们以前报道的两性离子羧基甜菜碱二甲基丙烯酸酯交联剂的设计和合成，我们表明，它的使用与两性离子羧基甜菜碱甲基丙烯酸酯导致无污垢的水凝胶具有高机械性能和高水合。现在，我们使用光聚合来提高聚合物网络的均匀性，从而大大提高了机械性能（压缩模量高达90 MPa）。此外，我们设计并合成了一种新的可官能化的羧基甜菜碱二甲基丙烯酸酯交联剂，使功能化的更高强度的水凝胶对无污染的背景。此外，测试了羧基甜菜碱水凝胶系统的生物稳定性，并且发现这些水凝胶在氧化、酸性和碱性环境中是稳定的。(C)2011爱思唯尔有限公司版权所有。
We reported previously the design and synthesis of a zwitterionic carboxybetaine dimethacrylate crosslinker, and we showed that its use with zwitterionic carboxybetaine methacrylate led to nonfouling hydrogels with high mechanical properties and high hydration. Now, we use photopolymerization to improve the uniformity of the polymer network, resulting in drastically improved mechanical properties (compressive modulus up to 90 MPa). Furthermore, we designed and synthesized a new functionalizable carboxybetaine dimethacrylate crosslinker, enabling functionalization of the higher strength hydrogels against a nonfouling background. Additionally, the biostability of the carboxybetaine hydrogel systems was tested, and it was found that these hydrogels are stable in oxidative, acidic, and basic environments. (C) 2011 Elsevier Ltd. All rights reserved.