Recent Advances in Stimuli-Sensitive Amphiphilic Polymer-Paclitaxel Prodrugs.
Recent Advances in Stimuli-Sensitive Amphiphilic Polymer-Paclitaxel Prodrugs.
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刺激敏感两亲性聚合物紫杉醇前药的最新进展
DOI：
10.3389/fbioe.2022.875034
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发表时间：
2022
影响因子：
5.7
通讯作者：
Yi, Xiaoqing
中科院分区：
文献类型：
--
作者：
Zhou, Man;Wen, Lijuan;Wang, Cui;Lei, Qiao;Li, Yongxiu;Yi, Xiaoqing
紫杉醇（PTX）是一种广谱化疗药物，用于治疗各种肿瘤。然而，PTX的水溶性差限制了其临床应用。佐剂被广泛用于克服这个问题。然而，这些佐剂通常具有副作用和不良的生物分布。智能给药系统是改善药物溶解性、渗透性和稳定性的一种很有前途的策略，可以促进药物的持续控制释放，提高疗效，减少副作用。聚合物前药由于其高载药量和稳定性而在药物传递方面显示出巨大的优势。在基于PTX的刺激敏感性聚合物前药胶束的开发方面有一些突破性的工作，在本研究中进行了总结。我们认为这些方面的四个主要类型的刺激（pH值，还原，酶和活性氧（ROS））。本文综述了PTX刺激响应性高分子前药的设计、合成及其在生物医学中的应用，并对该领域的研究现状和发展方向进行了总结。
Paclitaxel (PTX) is a broad-spectrum chemotherapy drug employed in the treatment of a variety of tumors. However, the clinical applications of PTX are limited by its poor water solubility. Adjuvants are widely used to overcome this issue. However, these adjuvants often have side effects and poor biodistribution. The smart drug delivery system is a promising strategy for the improvement of solubility, permeability, and stability of drugs, and can promote sustained controlled release, increasing therapeutic efficacy and reducing side effects. Polymeric prodrugs show great advantages for drug delivery due to their high drug loading and stability. There has been some groundbreaking work in the development of PTX-based stimulus-sensitive polymeric prodrug micelles, which is summarized in this study. We consider these in terms of the four main types of stimulus (pH, reduction, enzyme, and reactive oxygen species (ROS)). The design, synthesis, and biomedical applications of stimulus-responsive polymeric prodrugs of PTX are reviewed, and the current research results and future directions of the field are summarized.
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