Susceptibility of medical students to vaccine-preventable viral diseases: a serological study
Susceptibility of medical students to vaccine-preventable viral diseases: a serological study
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DOI：
10.1007/s10156-004-0347-x
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发表时间：
2004-12-01
影响因子：
2.2
通讯作者：
Hayashida, Yasuo
中科院分区：
文献类型：
--
作者：
Kukino, Junko;Naito, Toshio;Hayashida, Yasuo
作为医学院学生医院感染的预防和控制措施，我们检测了学生的麻疹、风疹、水痘和流行性腮腺炎病毒抗体滴度，以确定是否需要接种疫苗。我们还分析和讨论了病毒抗体滴度之间的相关性。受试者为 363 名顺天堂大学学生，涵盖从一年级到四年级的学生。 EIA用于测量IgG抗体滴度。 8 名受试者（2.2%）的麻疹滴度为阴性，36 名受试者（9.9%）的风疹滴度为阴性，8 名受试者（2.2%）的水痘滴度为阴性，10 名受试者（2.7%）的腮腺炎滴度为阴性。血清阴性受试者接种了每种病毒的疫苗，并获得了高血清转化率：麻疹和风疹为 100%，水痘为 67%，腮腺炎为 89%。此外，我们使用皮尔逊检验来寻找每种病毒的抗体滴度之间的相关性。麻疹、风疹和流行性腮腺炎的抗体滴度之间观察到弱相关性，但水痘的抗体滴度则没有。这些结果表明，MMR 疫苗可能对麻疹、风疹和腮腺炎抗体水平较低的人有效。
As a measure for the prevention and control of nosocomial infections in medical school students, we examined the students' titers of antibodies to measles, rubella, varicella, and mumps viruses to determine whether vaccination was required. We also analyzed and discussed correlations among antibody titers to the viruses. Subjects were 363 Juntendo University students, ranging from freshmen to seniors. EIA was used to measure IgG antibody titers. Eight subjects (2.2%) had negative titers for measles, 36 (9.9%) for rubella, 8 (2.2%) for varicella, and 10 (2.7%) for mumps. Seronegative subjects were vaccinated against each virus and high seroconversion rates were obtained: 100% for measles and rubella, 67% for varicella, and 89% for mumps. In addition, we used Pearson's test to search for correlations among the antibody titers for each virus. A weak correlation was observed among antibody titers for measles, rubella, and mumps but not for varicella. These results suggest that MMR vaccine might be effective in people with low levels of antibody to measles, rubella, and mumps.