The intra-day dynamics of affect, self-esteem, tiredness, and suicidality in Major Depression
The intra-day dynamics of affect, self-esteem, tiredness, and suicidality in Major Depression
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DOI：
10.1016/j.psychres.2018.02.032
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发表时间：
2019-09-01
影响因子：
11.3
通讯作者：
Malone, Kevin M.
中科院分区：
文献类型：
--
作者：
Crowe, Eimear;Daly, Michael;Malone, Kevin M.
尽管人们对重性抑郁症（MDD）的时间动态越来越感兴趣，但我们对关键症状结构的日内波动知之甚少。在一项关于瞬间体验的研究中，体验抽样方法捕获了临床MDD（N=31）和健康对照组（N=33）的消极情感、积极情感、自尊、被动自杀和疲劳的日内动态。在6天内每天进行10次症状测量（N=2231次观察）。每日动态通过一天内的时间趋势，变异性和症状的不稳定性进行建模。MDD参与者在消极情感、积极情感、自尊和自杀倾向方面表现出显著增加的变异性和不稳定性。在积极影响（增加的昼夜变化和倒U形模式的MDD，相比之下，在控制的积极的线性趋势）和疲劳（减少MDD的昼夜变化）中发现了显着不同的时间趋势。在抑郁症组中，被动自杀倾向呈负线性趋势，自尊呈二次倒U型趋势。因此，MDD和对照组参与者在所有测量的症状中表现出不同的动态特征。除了症状的总体严重程度外，日间动力学似乎也可以定义MDD症状的经历。
Despite growing interest in the temporal dynamics of Major Depressive Disorder (MDD), we know little about the intra-day fluctuations of key symptom constructs. In a study of momentary experience, the Experience Sampling Method captured the within-day dynamics of negative affect, positive affect, self-esteem, passive suicidality, and tiredness across clinical MDD (N=31) and healthy control groups (N=33). Ten symptom measures were taken per day over 6 days (N=2231 observations). Daily dynamics were modeled via intra-day time-trends, variability, and instability in symptoms. MDD participants showed significantly increased variability and instability in negative affect, positive affect, self-esteem, and suicidality. Significantly different time-trends were found in positive affect (increased diurnal variation and an inverted U-shaped pattern in MDD, compared to a positive linear trend in controls) and tiredness (decreased diurnal variation in MDD). In the MDD group only, passive suicidality displayed a negative linear trend and self-esteem displayed a quadratic inverted U trend. MDD and control participants thus showed distinct dynamic profiles in all symptoms measured. As well as the overall severity of symptoms, intra-day dynamics appear to define the experience of MDD symptoms.