Contributions of nucleus accumbens core, and shell GluR1 containing AMPA receptors in AMPA- and cocanine-primed reinstatement of cocaine-seeking behavior
Contributions of nucleus accumbens core, and shell GluR1 containing AMPA receptors in AMPA- and cocanine-primed reinstatement of cocaine-seeking behavior
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DOI：
10.1016/j.brainres.2008.03.088
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发表时间：
2008-06-18
期刊：
影响因子：
2.9
通讯作者：
Kruzich, Paul J.
中科院分区：
文献类型：
--
作者：
Ping, Ansong;Xi, Jinlei;Kruzich, Paul J.
谷氨酸信号在脑桥核的影响恢复先前熄灭可卡因寻求行为大鼠。是否区域特异性谷氨酸信号传导在脑桥核有助于可卡因寻求行为的恢复尚不清楚。我们研究了直接刺激延髓核芯或壳内的离子型谷氨酸受体（GluRs）是否会对灭绝训练后的重新可卡因寻求行为产生差异性影响。我们还测试了一个假设，即GluR 1亚基（GluR 1）含有α-氨基-3-羟基-5-甲基异恶唑-4-丙酸（AMPA）受体在核内的多巴胺核心，而不是外壳调节恢复以前熄灭的可卡因寻求行为。将AMPA微量注射到杏仁核壳和杏仁核芯中，剂量依赖性地引起显著的可卡因觅药行为。针对GluR 1亚基mRNA的反义寡核苷酸（AS）管理到核心和外壳破坏AMPA和可卡因引发的恢复，最显着的影响，在核壳。这些结果表明，GluRs的核内的核壳和影响AMPA和可卡因引发的恢复，但核壳发挥优势的核内的核壳。(c)2008 Elsevier B. V.保留所有权利。
Glutamate signaling in the nucleus accumbens influences reinstatement of previously extinguished cocaine-seeking behavior in rats. Whether or not region specific glutamate signaling in the nucleus accumbens contributes to reinstatement of cocaine-seeking behavior is not known. We investigated whether directly stimulating ionotropic glutamate receptors (GluRs) within the nucleus accumbens core or shell would differentially influence renewed cocaine-seeking behavior following extinction training. We also tested the hypothesis that GluR1 subunit (GluR1) containing alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) receptors in the nucleus accumbens core and not the shell regulate reinstatement of previously extinguished cocaine-seeking behavior. Microinjection of AMPA into the nucleus accumbens shell and the nucleus accumbens core dose-dependently elicited significant cocaine-seeking behavior. Administration of antisense oligonucleotides (AS) directed against GluR1 subunit mRNA into the core and shell disrupted AMPA- and cocaine-primed reinstatement-with the most pronounced effects seen in the nucleus accumbens shell. These results demonstrate that GluRs in the nucleus accumbens core and shell influence AMPA- and cocaine-primed reinstatement, yet the nucleus accumbens shell exerts a prepotency over the nucleus accumbens core. (c) 2008 Elsevier B.V. All rights reserved.