Future perspectives of a cardiac non-neuronal acetylcholine system targeting cardiovascular diseases as an adjunctive tool for metabolic intervention.
Future perspectives of a cardiac non-neuronal acetylcholine system targeting cardiovascular diseases as an adjunctive tool for metabolic intervention.
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DOI：
10.1016/j.intimp.2015.05.029
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发表时间：
2015-11
影响因子：
5.6
通讯作者：
Y. Kakinuma
中科院分区：
文献类型：
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作者：
Y. Kakinuma
自从几个研究小组独立报道心肌细胞中非神经元胆碱能系统的功能以来，已经有几年了。虽然这些发现最初似乎是微不足道的，但随后在涉及敲除非神经元胆碱能系统的研究中报告了关于心肌细胞的非凡发现。这些研究提供的证据表明，这一系统可能是必不可少的维持主要心脏功能。尽管没有一个适当的和可靠的技术来检测细胞乙酰胆碱在心肌细胞中的真实的时间，该系统的研究取得了进展，虽然非常缓慢，逐步巩固该系统的意义。基于这一系统的许多重要发现，这些将是关键的发展连续干预治疗心血管疾病，包括外周动脉疾病和心力衰竭。在这项研究中，以前的研究集中在非神经元胆碱能系统的审查沿着我们的研究，都表明心脏非神经元乙酰胆碱系统的生物学意义的作用，从临床的角度。
It has been several years since the function of the non-neuronal cholinergic system was independently reported in cardiomyocytes by several research groups. Although these findings initially seemed to be negligible and insignificant, extraordinary findings about cardiomyocytes were subsequently reported in studies involving the knockdown of the non-neuronal cholinergic system. These studies provide the evidence that this system may be indispensable for maintaining principal cardiac functions. Despite the absence of an appropriate and reliable technology to detect cellular ACh in real time in cardiomyocytes, studies of this system have progressed, albeit very slowly, to gradually consolidate the significance of this system. Based on the many significant findings regarding this system, these will be critical to develop adjunctive intervention therapy against cardiovascular diseases, including peripheral artery disease and heart failure. In this study, previous studies focusing on the non-neuronal cholinergic system are reviewed along with our studies, both indicating the biologically significant roles of the cardiac non-neuronal acetylcholine system from a clinical perspective.