Inhibition by retinoids of the growth of azaserine-induced foci in the rat pancreas.
Inhibition by retinoids of the growth of azaserine-induced foci in the rat pancreas.
复制标题
类维生素A抑制大鼠胰腺中重氮丝氨酸诱导的病灶的生长。
DOI：
10.1093/jnci/73.1.233
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
D. Longnecker
中科院分区：
文献类型：
--
作者：
B. Roebuck;K. J. Baumgartner;C. Thron;D. Longnecker
检查了短期阿扎胞苷[CAS：115 - 02 - 6;重氮乙酸丝氨酸（酯）]-大鼠模型用于筛选类维生素A（已知化学预防剂）的有用性，以及两种类维生素A对阿扎胞苷诱导的腺泡细胞假定癌前病灶生长的影响。在14日龄时，对雄性刘易斯大鼠每只注射30 mg氮杂环丁烷/kg体重的单次剂量。将这些大鼠断奶以测试添加了类维生素A的饮食。开始后4个月，通过定量体视学方法检查胰腺，以确定病灶的数量和平均大小。观察到两个表型不同的病灶群体，并将其表征为嗜酸性或嗜碱性。亚视黄基二甲酮和N-2-羟乙基视黄酰胺减少嗜酸性病灶的数量和大小，但不减少嗜碱性病灶。在长期致癌性研究中，对嗜酸性病灶生长的抑制与这些类维生素A的已知作用密切相关。
The usefulness of a short-term azaserine [CAS: 115-02-6; diazoacetate serine (ester)]-rat model for the screening of retinoids (known chemopreventive agents) and the effect of two retinoids on the growth of azaserine-induced, presumptive preneoplastic foci of acinar cells were examined. At 14 days of age, male Lewis rats were each given injections of a single dose of 30 mg azaserine/kg body weight. These rats were weaned to test diets to which retinoids were added. At 4 months post initiation, pancreata were examined by quantitative stereologic methods to determine number and mean size of foci. Two phenotypically different populations of foci were observed and characterized as acidophilic or basophilic. Retinylidene dimedone and N-2-hydroxyethylretinamide decreased the number and size of the acidophilic foci but not the basophilic foci. The inhibition of growth of the acidophilic foci correlates well with the known effects of these retinoids in long-term carcinogenicity studies.