Maladaptive effects of learning with the less-affected forelimb after focal cortical infarcts in rats
Maladaptive effects of learning with the less-affected forelimb after focal cortical infarcts in rats
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DOI：
10.1016/j.expneurol.2007.10.010
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发表时间：
2008-03-01
影响因子：
5.3
通讯作者：
Jones, Theresa A.
中科院分区：
文献类型：
--
作者：
Allred, Rachel P.;Jones, Theresa A.
中风后，早期康复工作通常集中于对受影响较小的身体一侧进行代偿性使用，这是很常见的。在这里，我们使用局灶性皮质梗塞的大鼠模型来检查受影响较小（“完整”）前肢的运动技能习得如何影响梗塞受损前肢的感觉运动功能和梗塞周围皮质的神经活动。能够熟练地用一只前肢伸手的大鼠在对侧感觉运动皮层（SMC）中受到局灶性缺血损伤。经过一段时间的集中于完整前肢或控制程序的伸展训练后，测试了该前肢的恢复情况。累积表达的转录因子 FosB/Delta FosB 的定量测量用于测定完整前肢训练对梗塞半球剩余 SMC 神经元活动的影响。完整的前肢训练会恶化单侧局灶性缺血后受损前肢的行为恢复。此外，它还降低了心梗周围 SMC II/III 层神经元 FosB/Delta FosB 的表达。在用双前肢顺序训练的假手术大鼠或在单侧梗塞后接受双侧前肢训练的动物中没有发现这些效应。因此，集中使用完整的前肢对局灶性缺血性损伤后受损的前肢功能的恢复具有不利影响，这与剩余皮质中神经元激活的减少有关。这些结果表明，梗塞周围皮层变得容易受到中风后早期经历影响较小的前肢的影响，并且这种经历可能会驱动这里的神经可塑性朝着不适应功能结果的方向发展。 (c) 2007 Elsevier Inc. 保留所有权利。
It is common following stroke to focus early rehabilitation efforts on developing compensatory use of the less-affected body side. Here we used a rat model of focal cortical infarct to examine how motor skill acquisition with the less-affected ("intact") forelimb influences sensorimotor function of the infarct-impaired forelimb and neural activity in peri-infarct cortex. Rats proficient in skilled reaching with one forelimb were given focal ischemic lesions in the contralateral sensorimotor cortex (SMC). Recovery in this forelimb was tested following a period of reach training focused on the intact forelimb or control procedures. Quantitative measures of the cumulatively expressed transcription factor, FosB/Delta FosB, were used to assay intact forelimb training effects on neuronal activity in remaining SMC of the infarcted hemisphere. Intact forelimb training worsened behavioral recovery in the impaired forelimb following unilateral focal ischemia. Furthermore, it decreased neuronal FosB/Delta FosB expression in layer II/III of peri-infaret SMC. These effects were not found in sham-operated rats trained sequentially with both forelimbs or in animals receiving bilateral forelimb training after unilateral infarcts. Thus, focused use of the intact forelimb has detrimental effects on recovery of impaired forelimb function following a focal ischemic injury and this is linked to reduced neuronal activation in remaining cortex. These results suggest that peri-infarct cortex becomes vulnerable to early post-stroke experience with the less-affected forelimb and that this experience may drive neural plasticity here in a direction that is maladaptive for functional outcome. (c) 2007 Elsevier Inc. All rights reserved.