Alzheimer disease: quantitative H-1 MR spectroscopic imaging of frontoparietal brain.
Alzheimer disease: quantitative H-1 MR spectroscopic imaging of frontoparietal brain.
复制标题
阿尔茨海默病：额顶叶脑的定量 H-1 MR 光谱成像。
DOI：
10.1148/radiology.207.1.9530304
复制
发表时间：
1998
期刊：
影响因子：
19.7
通讯作者：
Weiner,MW
中科院分区：
文献类型：
--
作者：
Schuff,N;Amend,DL;Meyerhoff,DJ;Tanabe,JL;Norman,D;Fein,G;Weiner,MW
目的复制先前阿尔茨海默病 (AD) 患者代谢异常的氢 1 磁共振 (MR) 波谱成像结果，验证代谢异常不是 MR 成像测量的结构变异的伪影，确定代谢变化是否与痴呆严重程度相关，并测试 MR 成像和 MR 波谱成像结果是否共同提高区分 AD 的能力。 材料和方法 在 28 名 AD 患者和 22 名患者中进行了 MR 波谱成像和 MR 成像。健康的老年受试者。将光谱成像数据与 MR 成像分割数据进行配准，以获得体积校正的代谢物浓度。 结果与之前的结果一致，AD 患者额叶和后内侧皮质中的 N-乙酰天冬氨酸 (NAA) 水平在统计学上显着降低，可能是由于神经元损失。 NAA 水平的降低与 MR 成像测量的结构变化无关，并且在顶叶内侧皮质中，与痴呆的严重程度轻度相关。与单独使用 MR 成像相比，NAA 水平的光谱成像结果与 MR 成像测量相结合并没有提高 AD 的辨别能力。 结论 额顶叶 NAA 水平降低对于 AD 的诊断作用有限。然而，它们并不是结构变异的产物，因此可能为理解 AD 的病理过程提供有用的信息。
PURPOSETo replicate previous hydrogen-1 magnetic resonance (MR) spectroscopic imaging findings of metabolic abnormalities in patients with Alzheimer disease (AD), to verify that metabolic abnormalities are not an artifact of structural variations measured at MR imaging, to determine whether metabolic changes correlate with dementia severity, and to test whether MR imaging and MR spectroscopic imaging findings together improve ability to differentiate AD.MATERIALS AND METHODSMR spectroscopic imaging and MR imaging were performed in 28 patients with AD and 22 healthy elderly subjects. Spectroscopic imaging data were coregistered with MR imaging segmentation data to obtain volume-corrected metabolite concentrations.RESULTSConsistent with previous results, N-acetyl aspartate (NAA) levels were statistically significantly reduced in frontal and posterior mesial cortex of AD patients, presumably due to neuronal loss. NAA level reductions were independent of structural variations measured at MR imaging and, in parietal mesial cortex, were correlated mildly with dementia severity. Spectroscopic imaging findings of NAA level combined with MR imaging measures did not improve discrimination power for AD relative to that of MR imaging alone.CONCLUSIONReduced NAA levels in frontoparietal brain are of limited use for diagnosis of AD. However, they are not an artifact of structural variations and thus may provide useful information for the understanding of the pathologic processes underlying AD.