Diagnostic Values of Free Triiodothyronine and Free Thyroxine and the Ratio of Free Triiodothyronine to Free Thyroxine in Thyrotoxicosis.
Diagnostic Values of Free Triiodothyronine and Free Thyroxine and the Ratio of Free Triiodothyronine to Free Thyroxine in Thyrotoxicosis.
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游离三碘甲状腺原氨酸和游离甲状腺素及游离三碘甲状腺原氨酸与游离甲状腺素的比值对甲状腺毒症的诊断价值
DOI：
10.1155/2018/4836736
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发表时间：
2018
影响因子：
2.8
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Chen X;Zhou Y;Zhou M;Yin Q;Wang S
背景以往关于游离三碘甲状腺原氨酸（FT3）对游离甲状腺素（FT4）有效性的研究结果存在争议。我们研究了FT3、FT4和FT3/FT4比值在鉴别Graves病（GD）和破坏性甲状腺炎中的作用。方法选取未经治疗的GD患者126例，无痛性甲状腺炎患者36例，疼痛性亚急性甲状腺炎患者18例，健康对照63例。采用受试者工作特征（ROC）曲线分析，分别评价不同病因甲状腺毒症患者的FT3、FT4水平及FT3/FT4比值。研究了甲状腺组织中1型和2型脱碘酶（DIO1和DIO2）的表达水平。结果FT3最佳临界值为7.215 pmol/L， FT4最佳临界值为21.71 pmol/L， FT3/FT4最佳临界值为0.4056。FT3/FT4比值的特异性和阳性预测值在> 0.4056时最高。GD患者甲状腺组织中DIO1 mRNA表达显著升高（P = 0.013）。结论FT3/FT4比值可用于鉴别GD与破坏性甲状腺炎。此外，甲状腺中1型脱碘酶的相对高表达可能是GD患者FT3/FT4比值高的原因。
Background The results of previous studies on the usefulness of free triiodothyronine (FT3) to free thyroxine (FT4) are controversial. We investigated the usefulness of FT3, FT4, and FT3/FT4 ratio in differentiating Graves' disease (GD) from destructive thyroiditis. Methods A total of 126 patients with untreated GD, 36 with painless thyroiditis, 18 with painful subacute thyroiditis, and 63 healthy controls, were recruited. The levels of FT3 and FT4 and the FT3/FT4 ratios for the different etiologies of thyrotoxicosis were evaluated separately by receiver operating characteristic (ROC) curve analysis. The expression levels of type 1 and type 2 deiodinase (DIO1 and DIO2) in thyroid tissues were also investigated. Results The optimal cut-off values were 7.215 pmol/L for FT3, 21.71 pmol/L for FT4, and 0.4056 for the FT3/FT4 ratio. The specificity and positive predictive value of the FT3/FT4 ratio were highest for values > 0.4056. DIO1 mRNA expression was significantly higher in the thyroid tissue of patients with GD (P = 0.013). Conclusions We demonstrated that the FT3/FT4 ratio was useful in differentiating GD from destructive thyroiditis. In addition, a relatively high expression of type 1 deiodinase in the thyroid might be responsible for the high FT3/FT4 ratio in patients with GD.
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影响因子：
6.6
作者：
Ross, Douglas S.;Burch, Henry B.;Walter, Martin A.
通讯作者：
Walter, Martin A.
影响因子：
2
作者：
Noh, JY;Momotani, N;Amino, N
通讯作者：
Amino, N
DOI：
10.1016/j.amsu.2016.07.024
发表时间：
2016-09
期刊：
Annals of medicine and surgery (2012)
影响因子：
--
作者：
Sriphrapradang C;Bhasipol A
通讯作者：
Bhasipol A
影响因子：
4.8
作者：
Canettieri, G;Celi, FS;Centanni, M
通讯作者：
Centanni, M
影响因子：
15.9
作者：
Salvatore, D;Tu, H;Larsen, PR
通讯作者：
Larsen, PR