Homeobox protein, Hmx3, in postnatally developing rat submandibular glands.
Homeobox protein, Hmx3, in postnatally developing rat submandibular glands.
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出生后发育的大鼠颌下腺中的同源框蛋白 Hmx3。
DOI：
10.1177/002215540305100313
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Williams,Valerie
中科院分区：
文献类型：
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作者：
Shaw,PhyllisA;Zhang,Xu;Russo,AndrewF;Amendt,BradA;Henderson,Scott;Williams,Valerie
同源异型盒基因在发育过程中起重要作用，特别是在神经元和感觉器官的发育以及身体计划的规范中。Hmx基因家族是一类新的含同源框基因，其由保守的同源框区域和在中枢神经系统中比Hox基因更喙侧的特征性表达模式定义。迄今为止，Hmx家族的三个密切相关的成员，Hmx1，Hmx2和Hmx3，已被描述。所有三个Hmx基因表达在发育胚胎的颅面区域。在这里，我们显示，第一次，转录因子Hmx3的表达在出生后发育的唾液腺。Hmx3蛋白在大鼠唾液腺中以细胞类型特异性方式表达。Hmx3存在于下颌下腺、腮腺和舌下腺的特定导管细胞群的细胞核和细胞质中。Hmx3在生后下颌下腺发育过程中表达增加。导管细胞显示随着下颌下腺的进行性发育，Hmx3蛋白浓度增加。相比之下，三种唾液腺的腺泡细胞不表现出可检测水平的Hmx3蛋白。
Homeobox-containing (Hox) genes play important roles in development, particularly in the development of neurons and sensory organs, and in specification of body plan. The Hmx gene family is a new class of homeobox-containing genes defined by a conserved homeobox region and a characteristic pattern of expression in the central nervous system that is more rostral than that of the Hox genes. To date, three closely related members of the Hmx family, Hmx1, Hmx2, and Hmx3, have been described. All three Hmx genes are expressed in the craniofacial region of developing embryos. Here we show, for the first time, the expression of the transcription factor Hmx3 in postnatally developing salivary glands. Hmx3 protein is expressed in a cell type-specific manner in rat salivary glands. Hmx3 is present in both the nuclei and cytoplasm of specific groups of duct cells of the submandibular, parotid, and sublingual glands. Hmx3 expression increases during postnatal development of the submandibular gland. The duct cells show increasing concentrations of Hmx3 protein with progressive development of the submandibular gland. In contrast, the acinar cells of the three salivary glands do not exhibit detectable levels of Hmx3 protein.