DEMONSTRATION OF VIRAL-ANTIGEN AND IMMUNOGLOBULIN (IGG AND IGM) IN BRAIN-TISSUE OF PIGS EXPERIMENTALLY INFECTED WITH HEMAGGLUTINATING ENCEPHALOMYELITIS VIRUS
DEMONSTRATION OF VIRAL-ANTIGEN AND IMMUNOGLOBULIN (IGG AND IGM) IN BRAIN-TISSUE OF PIGS EXPERIMENTALLY INFECTED WITH HEMAGGLUTINATING ENCEPHALOMYELITIS VIRUS
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DOI：
10.1016/0021-9975(89)90122-9
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发表时间：
1989-02-01
影响因子：
0.8
通讯作者：
KOBAYASHI, M
中科院分区：
文献类型：
--
作者：
NARITA, M;KAWAMURA, H;KOBAYASHI, M
用血凝性脑脊髓炎病毒（HEV）经口或鼻内接种10头3日龄无菌仔猪。所有受感染的猪均表现出食欲不振和精神萎靡，但没有神经紊乱的临床体征。在脑干和大脑皮层观察到严重的脑脊髓炎，其特征在于神经元吞噬、局灶性胶质增生和血管周围套。特别是鼻感染猪，在嗅纹和嗅束区域出现病变。与脑炎的变化相一致，HEV抗原首先在三叉神经节细胞中观察到，然后在变性的神经元中观察到。免疫球蛋白（IgG和IgM）的细胞也被发现在血管周围袖口和神经胶质病灶。它们最初出现在PID 7上，之后数量增加。这些结果表明，这些脑炎病变是一个特定的免疫反应，戊型肝炎病毒后，在中枢神经系统的繁殖。
Haemagglutinating encephalomyelitis virus (HEV) was inoculated either orally or intranasally into ten 3-day-old gnotobiotic piglets. All infected pigs showed inappetence and listlessness, but there were no clinical signs of nervous disorder. Severe encephalomyelitis, characterized by neuronophagia, focal gliosis and perivascular cuffing, was observed in the brain stem and cerebral cortex. Nasally infected pigs, in particular, developed lesions in the area of the stria olfactoria and tractus olfactorius. Coincident with the encephalitic changes, HEV antigen was observed first in the trigeminal ganglion cells and then in degenerating neurones. Immunoglobulin (IgG and IgM)-containing cells were also found in perivascular cuffs and glial foci. They appeared at first on PID 7 and after that increased in number. These findings suggest that these encephalitic lesions are a specific immune response to HEV following its multiplication in the central nervous system.