Toxicity and kinetics of methoxyfenozide in greenhouse-selected Spodoptera exigua (Lepidoptera: Noctuidae)
Toxicity and kinetics of methoxyfenozide in greenhouse-selected Spodoptera exigua (Lepidoptera: Noctuidae)
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DOI：
10.1002/ps.756
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发表时间：
2003-11-01
影响因子：
4.1
通讯作者：
Viñuela, E
中科院分区：
文献类型：
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作者：
Smagghe, G;Pineda, S;Viñuela, E
甲氧虫酰肼（RH-2485）被认为是7.5倍，毒性低的LD 50值对末龄幼虫的温室选择株的甜菜夜蛾。甜菜夜蛾（Hubner），收集在2001年7月在西班牙南部的穆尔西亚的一个实验室温室的电阻，在与实验室敏感株。到目前为止，该化合物是这组新的蜕皮激素加速IGRs的最新成员，以达到市场对鳞翅目昆虫。为了了解这种不同的效力在温室选择的甜菜，氧化代谢和乙酰胆碱酯酶活性测定末龄幼虫和成人。此外，我们确定，通过使用C-14-标记甲氧虫酰肼，在身体组织中的吸收和排泄的模式，通过温室选择的菌株的末龄幼虫，并与实验室敏感菌株的结果进行比较。令人惊讶的是，温室选择的菌株的排泄率大约是温室选择的菌株的两倍，导致杀虫剂从昆虫体内的清除速度更快。数据进行了讨论，这一新的IGRs组的毒性较低的机制。(C)2003化学工业协会。
Methoxyfenozide (RH-2485) was found to be 7.5-fold less toxic in terms of LD50 values against last-instar larvae of a greenhouse-selected strain of the beet armyworm. Spodoptera exigua (Hubner) that was collected in July 2001 in an experimental greenhouse for resistance at Murcia in southern Spain, in comparison with a laboratory susceptible strain. To date, the compound is the newest member of this new group of moulting hormone accelerating IGRs to reach the marketplace against Lepidoptera. To understand this different potency in the greenhouse-selected S exigua, oxidative metabolism and acetylcholinesterase activities were measured in last-instar larvae and adults. In addition, we determined, by the use of C-14-labelled methoxyfenozide, the pattern of absorption in body tissues and excretion via faeces in last-instar larvae of the greenhouse-selected strain and compared the results with those from the laboratory susceptible strain. It was striking that the rate of excretion was about twice as high in the greenhouse-selected strain, resulting in a more rapid clearance of insecticide amounts from the insect body. Data are discussed in relation to mechanisms of lower toxicities for this new group of IGRs. (C) 2003 Society of Chemical Industry.