The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling
The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling
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DOI：
10.1093/bioinformatics/bti770
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发表时间：
2006-01-15
期刊：
影响因子：
5.8
通讯作者：
Schwede, T
中科院分区：
文献类型：
--
作者：
Arnold, K;Bordoli, L;Schwede, T
动机：蛋白质的同源模型在计划和分析生物学实验时非常兴趣，当时没有实验三维结构。构建同源模型需要专门的程序以及最新的序列和结构数据库。将所有必需的工具，程序和数据库集成到一个基于Web的工作区中专用于蛋白质结构同源性建模的综合服务。它有助于用户以不同级别的复杂性构建蛋白质同源性模型。为每个用户提供一个个人工作环境，可以并行进行多个建模项目。建模所需的蛋白质序列和结构数据库可从工作区访问，并定期更新。可以从工作区内调用用于模板选择，模型构建和结构质量评估的工具。通过建模人类细胞周期蛋白A1和人跨膜蛋白酶3来说明工作空间的工作流和使用。
Motivation: Homology models of proteins are of great interest for planning and analysing biological experiments when no experimental three-dimensional structures are available. Building homology models requires specialized programs and up-to-date sequence and structural databases. Integrating all required tools, programs and databases into a single web-based workspace facilitates access to homology modelling from a computer with web connection without the need of downloading and installing large program packages and databases.Results: SWISS-MODEL workspace is a web-based integrated service dedicated to protein structure homology modelling. It assists and guides the user in building protein homology models at different levels of complexity. A personal working environment is provided for each user where several modelling projects can be carried out in parallel. Protein sequence and structure databases necessary for modelling are accessible from the workspace and are updated in regular intervals. Tools for template selection, model building and structure quality evaluation can be invoked from within the workspace. Workflow and usage of the workspace are illustrated by modelling human Cyclin A1 and human Transmembrane Protease 3.