The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults
The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults
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DOI：
10.1164/rccm.200611-1627oc
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发表时间：
2007-08-15
影响因子：
24.7
通讯作者：
Tang, Chin-Sheng
中科院分区：
文献类型：
--
作者：
Chuang, Kai-Jen;Chan, Chang-Chuan;Tang, Chin-Sheng
空气污染与心血管事件的生物学机制目前仍不清楚。目的：探讨空气污染与心血管事件的生物学机制是否在暴露于城市空气污染的人群中同时发生。方法：我们招募了来自台北一所大学的76名年轻、健康的学生。于2004-04/2005-06对受试者进行超敏C反应蛋白(hs-CRP)、8-羟基-2‘-脱氧鸟苷(8-OHdG)、纤溶酶原激活物-1(PAI-1)、血浆组织型纤溶酶原激活物(TPA)、心率变异性(HRV)三项检测。在校园内的一个空气监测站测量了气态空气污染物，在距离校园1公里的颗粒物超标点测量了颗粒物空气污染物。我们使用线性混合效应模型将生物终点与单个空气污染物关联起来，平均在测量前1-3天内。测量和主要结果：我们发现，在单污染物模型中，hs-CRP、8-OHdG、纤维蛋白原和PAI-1的增加以及HRV指数的下降与空气动力学直径小于10微米和2.5微米的颗粒物、硫酸盐、硝酸盐和臭氧(03)的水平增加有关。在双污染物模型中，8-OHdG、纤维蛋白原和PAI-1的增加以及HRV的减少仍然与3天平均硫酸盐和03水平显著相关。血hs-CRP、纤维蛋白原、PAI-1与心率变异性指标呈中等相关(r=-0.3)。结论：城市空气污染同时与炎症、氧化应激、凝血和自主神经功能障碍有关，硫酸盐和03是与交通相关的两种主要污染物。
Rationale The biological mechanisms linking air pollution to cardiovascular events still remain largerly unclear.Objectives: To investigate whether biological mechanisms linking air pollution to cardiovascular events occurred concurrently in human subjects exposed to urban air pollutants.Methods: We recruited a panel of 76 young, healthy students from a university in Taipei. Between April and June of 2004 or 2005, three measurements were made in each participant of high-sensitivity C-reactive protein (hs-CRP), 8-hydroxy-2'-deoxyguanosine (8-OHdG), plasminogen activator fibrinogen inhibitor-1 (PAI-1), tissue-type plasminogen activator (tPA) in plasma, and heart rate variability (HRV). Gaseous air pollutants were measured at one air-monitoring station inside their campus, and particulate air pollutants were measured at one particulate matter supersite monitoring station I km from their campus. We used linear mixed-effects models to associate biological endpoints with individual air pollutants averaged over 1- to 3-day periods before measurements were performed.Measurements and Main Results: We found that increases in hs-CRP, 8-OHdG, fibrinogen, and PAI-1, and decreases in HRV indices were associated with increases in levels of particles with aerodynamic diameters less than 10 mu m and 2.5 mu m, sulfate, nitrate, and ozone (03) in single-pollutant models. The increase in 8-OHdG, fibrinogen, and PAI-1, and the reduction in HRV remained significantly associated with 3-day averaged sulfate and 03 levels in two-pollutant models. There were moderate correlations (r = -0.3) between blood markers of hs-CRP, fibrinogen, PAI-1, and HRV indices.Conclusions: Urban air pollution is associated with inflammation, oxidative stress, blood coagulation and autonomic dysfunction simultaneously in healthy young humans, with sulfate and 03 as two major traffic-related pollutants contributing to such effects.