Structural and Functional Brain Changes in Middle-Aged Type 2 Diabetic Patients: A Cross-Sectional Study
Structural and Functional Brain Changes in Middle-Aged Type 2 Diabetic Patients: A Cross-Sectional Study
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DOI：
10.3233/jad-131736
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发表时间：
2014-01-01
影响因子：
4
通讯作者：
Gonzalez-Santos, Pedro
中科院分区：
文献类型：
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作者：
Garcia-Casares, Natalia;Berthier, Marcelo L.;Gonzalez-Santos, Pedro
背景：2型糖尿病（T2 DM）是认知功能损害的一个新的危险因素。这种损害是否是这种代谢紊乱对脑功能的直接影响，血管疾病的后果，或两者兼而有之，仍然未知。T2 DM患者的结构和功能的神经影像学研究可以帮助阐明这个问题。目的：我们设计了一个横断面研究比较25 T2 DM患者与25年龄和性别匹配的健康对照参与者。临床信息，APOE基因型，血脂和血糖分析，结构脑磁共振成像，包括体素为基础的形态学，和F-18氟脱氧葡萄糖正电子发射断层扫描获得在所有subjects.Methods：灰质密度和代谢组间的差异进行了分析，使用统计参数映射。除了比较两组的神经影像学资料，我们相关的神经影像学结果与HbA 1c水平，持续时间的T2 DM，和胰岛素抵抗测量（HOMA-IR）在糖尿病患者group.Results：T2 DM患者提出减少灰质密度和减少脑葡萄糖代谢在几个额颞叶脑区后，控制各种血管危险因素。此外，在T2 DM组，较长的病程，较高的HbA 1c水平和HOMA-IR与较低的灰质密度和脑葡萄糖代谢减少额颞regions.Conclusion：在协议与以前的报告，我们的研究结果表明，T2 DM导致结构和代谢异常额颞区。此外，他们认为这些异常不能完全由T2 DM作为心血管风险因素的作用来解释。
Background: Type 2 diabetes mellitus (T2DM) is an emerging risk factor for cognitive impairment. Whether this impairment is a direct effect of this metabolic disorder on brain function, a consequence of vascular disease, or both, remains unknown. Structural and functional neuroimaging studies in patients with T2DM could help to elucidate this question.Objective: We designed a cross-sectional study comparing 25 T2DM patients with 25 age-and gender-matched healthy control participants. Clinical information, APOE genotype, lipid and glucose analysis, structural cerebral magnetic resonance imaging including voxel-based morphometry, and F-18 fluorodeoxyglucose positron emission tomography were obtained in all subjects.Methods: Gray matter densities and metabolic differences between groups were analyzed using statistical parametric mapping. In addition to comparing the neuroimaging profiles of both groups, we correlated neuroimaging findings with HbA1c levels, duration of T2DM, and insulin resistance measurement (HOMA-IR) in the diabetic patients group.Results: Patients with T2DM presented reduced gray matter densities and reduced cerebral glucose metabolism in several fronto-temporal brain regions after controlling for various vascular risk factors. Furthermore, within the T2DM group, longer disease duration, and higher HbA1c levels and HOMA-IR were associated with lower gray matter density and reduced cerebral glucose metabolism in fronto-temporal regions.Conclusion: In agreement with previous reports, our findings indicate that T2DM leads to structural and metabolic abnormalities in fronto-temporal areas. Furthermore, they suggest that these abnormalities are not entirely explained by the role of T2DM as a cardiovascular risk factor.