Laparotomy-induced gastric protection against ethanol injury is mediated by capsaicin-sensitive sensory neurons.
Laparotomy-induced gastric protection against ethanol injury is mediated by capsaicin-sensitive sensory neurons.
复制标题
剖腹手术诱导的胃对乙醇损伤的保护是由辣椒素敏感的感觉神经元介导的。
DOI：
10.1016/0016-5085(90)91222-r
复制
发表时间：
1990
期刊：
影响因子：
29.4
通讯作者：
Guth,PH
中科院分区：
文献类型：
--
作者：
Yonei,Y;Holzer,P;Guth,PH
剖腹手术可显著减轻乙醇引起的大鼠胃粘膜病变。研究了辣椒素、吲哚美辛、阿托品、胍乙啶和六甲索铵对大鼠开腹保护作用的影响。用75%乙醇灌胃1 mL诱导大鼠胃粘膜损伤。辣椒素（总剂量，125 mg/kg， SC）和吲哚美辛（5 mg/kg， SC）预处理可以消除开腹术诱导的乙醇损伤保护作用。相比之下，阿托品（0.5 mg/kg， IP）、胍乙啶（总剂量，20mg /kg， SC）或六甲溴铵（20mg /kg， IP）预处理对开腹诱导的保护作用无显著影响。这些数据表明辣椒素敏感的感觉传入神经元，而不是胆碱能或肾上腺素能自主神经神经元，介导了剖腹手术诱导的对乙醇损伤的保护。假设剖腹手术的保护反应是由辣椒素敏感传入神经元的躯体内脏和/或内脏轴突反射引起的。前列腺素可能在剖腹手术激活传入神经元的躯体和/或内脏分支中起中介作用。
Laparotomy significantly attenuates ethanol-induced gastric mucosal lesions in the rat. The effects of sensory denervation by capsaicin, indomethacin, atropine, guanethidine, and hexamethonium on laparotomy-induced protection were studied in the rat. Gastric mucosal injury was induced by the intragastric instillation of 1 mL of 75% ethanol. The laparotomy-induced protection against ethanol injury was abolished by sensory denervation by capsaicin (total dose, 125 mg/kg, SC) and also by pretreatment with indomethacin (5 mg/kg, SC). In contrast, pretreatment with atropine (0.5 mg/kg, IP), guanethidine (total dose, 20 mg/kg, SC), or hexamethonium (20 mg/kg, IP) had no significant effect on laparotomy-induced protection. These data indicate that capsaicin-sensitive sensory afferent neurons, but not cholinergic or adrenergic autonomic neurons, mediate laparotomy-induced protection against ethanol injury. The hypothesis is put forward that the protective response to laparotomy arises from a somatovisceral and/or viscerovisceral axon reflex of capsaicin-sensitive afferent neurons. Prostaglandins might play a mediator role in the activation by laparotomy of somatic and/or visceral branches of the afferent neurons.