Single-neuron activity in the dorsomedial frontal cortex during smooth-pursuit eye movements to predictable target motion
Single-neuron activity in the dorsomedial frontal cortex during smooth-pursuit eye movements to predictable target motion
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DOI：
10.1017/s0952523800011597
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发表时间：
1997-09-01
影响因子：
1.9
通讯作者：
Liu, M
中科院分区：
文献类型：
--
作者：
Heinen, SJ;Liu, M
背内侧额叶皮层（DMFC）的一个区域与计划和执行跳眼运动有关；因此被称为辅助视野（SEF）。最近，DMFC记录了与执行平滑的眼球运动有关的活动，这里的微刺激已被证明能唤起平滑的眼球运动。本报告记录了在目标运动的可预测性被操纵的平滑追踪任务中存在的神经元活动。当目标运动发生可预测的变化时，DMFC中许多神经元的活动达到峰值。此外，通过控制目标事件的持续时间，一些细胞的峰值活动发生了系统的移动，这表明这些神经元所在的网络可以学习新的目标运动的时间特征。最后，当目标运动可预测时，大多数被测神经元的活动要比目标运动不可预测时更活跃。结果表明，DMFC参与了基于过去刺激历史的平滑追逐眼运动的规划。
A region of dorsomedial frontal cortex (DMFC) has been implicated in planning and executing saccadic eye movements; hence it has been referred to as a supplementary eye field (SEF). Recently, activity related to executing smooth-pursuit eye movements has been recorded from the DMFC, and microstimulation here has been shown to evoke smooth eye movements. This report documents neuronal activity present in smooth-pursuit tasks where the predictability of target motion was manipulated. The activity of many neurons in the DMFC reached a peak when a predictable change in target motion occurred. Furthermore, the peak activity of some cells was systematically shifted by manipulating the duration of the target event, indicating that the network these neurons were in could learn the temporal characteristics of new target motion. Finally, the activity of most neurons tested was greater when target motion was predictable than when it was unpredictable. The results suggest that the DMFC participates in planning smooth-pursuit eye movements based on past stimulus history.