Enantioselective monofluoromethylation of aldehydes with 2-fluoro-1,3-benzodithiole-1,1,3,3-tetraoxide catalyzed by a bifunctional cinchona alkaloid-derived thiourea-titanium complex.
Enantioselective monofluoromethylation of aldehydes with 2-fluoro-1,3-benzodithiole-1,1,3,3-tetraoxide catalyzed by a bifunctional cinchona alkaloid-derived thiourea-titanium complex.
复制标题
DOI：
10.1039/c3cc46544f
复制
发表时间：
2013-11
影响因子：
4.9
通讯作者：
Haiyan Ma;Kohei Matsuzaki;Yudong Yang;Etsuko Tokunaga;Daisuke Nakane;T. Ozawa;H. Masuda;N. Shibata
中科院分区：
文献类型：
--
作者：
Haiyan Ma;Kohei Matsuzaki;Yudong Yang;Etsuko Tokunaga;Daisuke Nakane;T. Ozawa;H. Masuda;N. Shibata
使用 2-氟-1,3-苯并二硫醇-1,1,3,3-四氧化物 (FBDT) 实现了醛的催化对映选择性单氟甲基化。采用双功能硫脲-钛催化体系，以良好的收率和高对映选择性（高达 96% ee）获得单氟甲基化加合物。
A catalytic enantioselective monofluoromethylation of aldehydes using 2-fluoro-1,3-benzodithiole-1,1,3,3-tetraoxide (FBDT) was realized. With a bifunctional thiourea-titanium catalytic system, the monofluoromethylated-adducts were obtained in good yields and high enantioselectivities, up to 96% ee.