Nesteretal A, A Novel Class of Cage-Like Polyketide from Marine-Derived Actinomycete Nesterenkonia halobia
Nesteretal A, A Novel Class of Cage-Like Polyketide from Marine-Derived Actinomycete Nesterenkonia halobia
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Nesteretal A，一种来自海洋源性放线菌 Nesterenkonia halobia 的新型笼状聚酮化合物。
DOI：
10.1021/acs.orglett.9b02634
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发表时间：
2019-10-18
期刊：
影响因子：
5.2
通讯作者：
Yang, Xian-Wen
中科院分区：
文献类型：
--
作者：
Xie, Chun-Lan;Chen, Renzhi;Yang, Xian-Wen
从珊瑚来源的嗜盐涅斯捷连科氏菌（Nesterenkonia halobia）中分离出一种有趣的笼状多缩酮半缩醛，涅斯捷列醇A（1）。其结构通过大量的光谱学和计算方法确定。涅斯捷列醇A是一种高度氧化的化合物，具有前所未有的5/5/5/5四环骨架。提出了一种从天然存在的丁二酮合成1的可能生物合成途径。化合物1显示出微弱的类视黄醇X受体-α（RXRα）转录激活作用。
An intriguing cage-like polyhemiketal, nesteretal A (1), was isolated from the coral-derived actinomycete Nesterenkonia halobia. Its structure was established by extensive spectroscopic and computational methods. Nesteretal A is a highly oxygenated compound featuring an unprecedented 5/5/5/5 tetracyclic scaffold. A possible biosynthetic pathway of 1 from naturally occurring diacetyl was proposed. Compound 1 showed a weak retinoid X receptor-α (RXRα) transcriptional activation effect.