Sonic hedgehog, apoptosis, and the penis.
Sonic hedgehog, apoptosis, and the penis.
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DOI：
10.1111/j.1743-6109.2008.01192.x
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Podlasek CA
中科院分区：
文献类型：
--
作者：
Podlasek CA
阴茎平滑肌细胞凋亡在阴茎切除术患者和勃起功能障碍（艾德）动物模型中很常见。阴茎平滑肌细胞凋亡的关键调节因子是分泌蛋白Sonic hedgehog（SHH）。由于SHH蛋白治疗阴茎防止海绵体神经（CN）损伤诱导的细胞凋亡，因此SHH具有治疗阴茎切除术后细胞凋亡的潜力。然而，关于SHH信号在成年阴茎中的调节方式知之甚少。本综述的目的是研究什么是已知的SHH信号在阴茎中，提供洞察SHH抑制如何诱导阴茎平滑肌细胞凋亡，并确定SHH通路在维持CN完整性的作用。本综述中提供的信息来自使用国家医学图书馆PubMed服务的文献检索。检索词包括SHH、细胞凋亡、平滑肌、阴茎、艾德、盆神经节、海绵体、CN、再生、雪旺细胞、神经活动和转运。在这篇综述中，我们讨论了在调节SHH丰度和细胞凋亡诱导的阴茎CN的作用，并检查了功能和定位的SHH信号在CN。有很大的潜力开发SHH用于在手术时递送到阴茎切除术患者的阴茎，以防止细胞凋亡诱导和长期艾德发展。研究正在进行中，将确定SHH是否可用作加速CN再生的再生疗法。
Smooth muscle apoptosis in the penis is common in prostatectomy patients and animal models of erectile dysfunction (ED). A critical regulator of smooth muscle apoptosis in the penis is the secreted protein Sonic hedgehog (SHH). Since SHH protein treatment of the penis prevents cavernous nerve (CN) injury induced apoptosis, SHH has the potential to treat post-prostatectomy apoptosis. However little is known about how SHH signaling is regulated in the adult penis. The goal of this review is to examine what is known about SHH signaling in the penis, to offer insight as to how SHH inhibition induces apoptosis in penile smooth muscle, and to define the role of the SHH pathway in maintaining CN integrity. Information presented in this review was derived from a literature search using the National Library of Medicine PubMed Services. Search terms included SHH, apoptosis, smooth muscle, penis, ED, pelvic ganglia, corpora cavernosa, CN, regeneration, Schwann cell, neural activity and transport. In this review we have discussed the role of the CN in regulation of SHH abundance and apoptosis induction in the penis and have examined the function and localization of SHH signaling in the CN. There is substantial potential to develop SHH for delivery to the penis of prostatectomy patients at the time of surgery in order to prevent apoptosis induction and long term ED development. Studies are in progress which will identify if SHH may be used as a regenerative therapy to speed CN regeneration.
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