Colorectal cancers survivors' adherence to lifestyle recommendations and cross-sectional associations with health-related quality of life
Colorectal cancers survivors' adherence to lifestyle recommendations and cross-sectional associations with health-related quality of life
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DOI：
10.1017/s0007114518000661
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发表时间：
2018-07-28
影响因子：
3.6
通讯作者：
Weijenberg, Matty P.
中科院分区：
文献类型：
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作者：
Breedveld-Peters, Jose J. L.;Koole, Janna L.;Weijenberg, Matty P.
世界癌症研究基金会（WCRF）/美国癌症研究所（AICR）的生活方式建议主要用于预防癌症。在没有针对癌症幸存者的具体建议的情况下，我们调查了结直肠癌（CRC）幸存者对WCRF/AICR生活方式建议的依从性以及与健康相关生活质量（HRQoL）的相关性。在155名诊断后2-10年的CRC幸存者（I-III期）中进行了结肠直肠癌后生命能量（EnCoRe）研究的横截面部分。饮食摄入量，体力活动和一般身体肥胖分别通过7-d食物日记，问卷调查和加速计和BMI测量。对10项WCRF/AICR建议的遵守情况均评分为0（无/低遵守）。0.5在一个实施例中，患者的依从性评分为1分（中等依从性）或1分（完全依从性），并求和为总体依从性评分（范围：0-10）。HRQoL，残疾和痛苦进行了评估的有效问卷。通过混杂因素调整线性回归分析总体WCRF/AICR依从性评分与HRQoL结局的相关性。平均依从性评分为5.1（SD 1.4，范围：1.5-8.5）。在混杂因素校正模型中，较高的依从性评分与HRQoL维度更好的身体功能（每1分的评分差异β：2.6; 95% CI 0.2，5.1）和更少的疲劳（β：-3.3; 95% CI-6.4，-0.1）显著相关。总之，CRC幸存者对WCRF/AICR癌症预防生活方式建议的更高依从性与更好的身体功能和更少的疲劳有关。这项研究增加了对CRC幸存者坚持生活方式行为及其与生活质量关系的有限了解。需要进行前瞻性研究来调查纵向关联。
The lifestyle recommendations of the World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) are primarily intended for cancer prevention. In the absence of specific recommendations for cancer survivors, we investigated adherence of colorectal cancer (CRC) survivors to the WCRF/AICR lifestyle recommendations and associations with health-related quality of life (HRQoL). The cross-sectional part of the Energy for life after ColoRectal cancer (EnCoRe) study was conducted in 155 CRC survivors (stage I-III), 2-10 years post diagnosis. Dietary intake, physical activity and general body fatness were measured by 7-d food diaries, by questionnaires and accelerometers and BMI, respectively. Adherence to each of the ten WCRF/AICR recommendations was scored as 0 (no/low adherence). 0.5 (moderate adherence) or 1 point (complete adherence), and summed into an overall adherence score (range: 0-10). HRQoL, disability and distress were assessed by validated questionnaires. Associations of the overall WCRF/AICR adherence score with HRQoL outcomes were analysed by confounder-adjusted linear regression. The mean adherence score was 5.1 (SD 1.4, range: 1.5-8.5). In confounder-adjusted models, a higher adherence score was significantly associated with the HRQoL dimension better physical functioning (beta per 1 point difference in score: 2.6; 95% CI 0.2, 5.1) and with less fatigue (beta: -3.3; 95% CI -6.4, -0.1). In conclusion, higher adherence of CRC survivors to WCRF/AICR lifestyle recommendations for cancer prevention was associated with better physical functioning and with less fatigue. This study adds to the limited knowledge on adherence to lifestyle behaviours in CRC survivors and relationships with quality of life. Prospective studies are needed to investigate longitudinal associations.