NEUTRON-DIFFRACTION IDENTIFIES HIS-57 AS THE CATALYTIC BASE IN TRYPSIN
NEUTRON-DIFFRACTION IDENTIFIES HIS-57 AS THE CATALYTIC BASE IN TRYPSIN
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DOI：
10.1038/288414a0
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发表时间：
1980-01-01
期刊：
影响因子：
64.8
通讯作者：
SPENCER, SA
中科院分区：
文献类型：
--
作者：
KOSSIAKOFF, AA;SPENCER, SA
这里给出的结果来自2.2 . ang。被过渡态类似物单异丙基磷基（MIP）共价抑制的牛胰蛋白酶的中子数据集。他的57被清楚地识别为催化过程中的碱基。
Results are presented here from a 2.2 .ANG. neutron data set for bovine trypsin covalently inhibited by a transition-state analog, the monoisopropylphosphoryl (MIP) group. His 57 is clearly identified as the base in the catalytic process.