Alcohol consumption in the general population is associated with structural changes in multiple organ systems.
Alcohol consumption in the general population is associated with structural changes in multiple organ systems.
复制标题
DOI：
10.7554/elife.65325
复制
发表时间：
2021-06-01
期刊：
影响因子：
7.7
通讯作者：
Elliott P
中科院分区：
文献类型：
--
作者：
Evangelou E;Suzuki H;Bai W;Pazoki R;Gao H;Matthews PM;Elliott P
过量饮酒与各种器官的损害有关，但其多器官效应尚未在大规模一般人群样本中的通常饮酒范围内进行表征。我们评估了饮酒对报告饮酒的英国生物银行参与者的大脑，心脏，主动脉和肝脏的定量磁共振成像表型测量的全球效应大小。我们发现，在酒精摄入量范围内，酒精摄入量越高，正常化脑体积越低（酒精摄入量每增加一倍，-1.7 × 10−3 ± 0.76 × 10−3，p=3.0 × 10−14）。饮酒量也与左心室质量指数、左心室和心房容积指数直接相关。酒精摄入量每增加一倍，肝脏脂肪平均增加0.15%。我们的研究结果表明，没有一个“安全阈值”，低于这个阈值，酒精就没有毒性作用。目前关于饮酒的公共卫生准则可能需要重新审查。参见注释。
Excessive alcohol consumption is associated with damage to various organs, but its multi-organ effects have not been characterised across the usual range of alcohol drinking in a large general population sample. We assessed global effect sizes of alcohol consumption on quantitative magnetic resonance imaging phenotypic measures of the brain, heart, aorta, and liver of UK Biobank participants who reported drinking alcohol. We found a monotonic association of higher alcohol consumption with lower normalised brain volume across the range of alcohol intakes (–1.7 × 10−3 ± 0.76 × 10−3 per doubling of alcohol consumption, p=3.0 × 10−14). Alcohol consumption was also associated directly with measures of left ventricular mass index and left ventricular and atrial volume indices. Liver fat increased by a mean of 0.15% per doubling of alcohol consumption. Our results imply that there is not a ‘safe threshold’ below which there are no toxic effects of alcohol. Current public health guidelines concerning alcohol consumption may need to be revisited. See acknowledgements.