Convenient Auditory-Based Language and Executive Function Test for Patients With Amyotrophic Lateral Sclerosis: A Pilot Study
Convenient Auditory-Based Language and Executive Function Test for Patients With Amyotrophic Lateral Sclerosis: A Pilot Study
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针对肌萎缩侧索硬化症患者的方便的基于听觉的语言和执行功能测试：一项试点研究
DOI：
10.1093/arclin/acac069
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发表时间：
2022
影响因子：
2.6
通讯作者：
Sobue Gen
中科院分区：
文献类型：
--
作者：
Ohdake Reiko;Watanabe Hirohisa;Kawabata Kazuya;Ogura Aya;Sato Maki;Tanaka Yasuhiro;Imai Kazunori;Masuda Michihito;Kato Toshiyasu;Yokoi Takamasa;Hara Kazuhiro;Nakamura Ryoichi;Atsuta Naoki;Nakagawa Masafumi;Katsuno Masahisa;Sobue Gen
大约30%-50%的肌萎缩侧索硬化症（ALS）患者表现出从轻度执行障碍综合征到额颞叶痴呆的认知障碍。我们的目的是开发一个简短的认知测试，方便的认知为基础的语言和执行功能测试（CABLET），用于快速检测认知障碍的ALS，减少负荷的运动function.MethodThe CABLET包括两个测试，使用听觉言语刺激：测试1，评估单词重复和词汇判断，和测试2，评估口头短期记忆和语义知识。试验1和试验2的给药时间分别为1和3-5 min。总体而言，61例ALS患者和46名年龄，性别和教育相匹配的健康对照参与了这项研究。所有参与者都接受了现有的神经心理学测试和CABLET。我们调查的适用性CABLET检测ALS与认知功能障碍（ALSci）从正常cognition.ResultsReceiver工作特征分析表明，CABLET总和测试2有良好的诊断准确性（曲线下面积[AUC]：总= 0.894，测试2 = 0.893）。试验2的敏感性最高（100%敏感性和71.4%特异性）。在有和没有年龄、教育程度和疾病严重程度作为协变量的分析中，AUC无显著差异。CABLET和建立的神经心理学测试之间的相关性进行了观察，支持其良好的收敛validity.ConclusionsOur研究结果表明，CABLET可以是有用的，在确定ALSci快速不调整混杂因素。需要进一步验证，以在更大的群体中进行评估，并与ALS特异性认知筛查进行比较。
ObjectiveAbout 30%–50% of patients with amyotrophic lateral sclerosis (ALS) show cognitive impairment ranging from mild dysexecutive syndrome to frontotemporal dementia. We aimed to develop a brief cognitive test, convenient auditory-based language and executive function test (CABLET), for rapid detection of cognitive impairment in ALS, with reduced load on motor function.MethodThe CABLET comprises two tests using auditory verbal stimuli: Test 1, assessing word repetition and lexical judgment, and Test 2, evaluating verbal short-term memory and semantics knowledge. The administration time of Test 1 and Test 2 was 1 and 3–5 min, respectively. Overall, 61 patients with ALS and 46 age-, sex-, and education-matched healthy controls participated in this study. All participants underwent existing neuropsychological tests and the CABLET. We investigated the applicability of the CABLET to detect ALS with cognitive impairment (ALSci) from normal cognition.ResultsReceiver operating characteristic analyses showed that both the CABLET total and Test 2 had good diagnostic accuracy (area under the curve [AUC]: total = 0.894, Test 2 = 0.893). Test 2 had the highest sensitivity (100% sensitivity and 71.4% specificity). No significant difference existed in the AUC between the analyses with and without age, education, and disease severity as covariates. Correlations were observed between the CABLET and established neuropsychological tests, supporting its good convergent validity.ConclusionsOur findings indicated that the CABLET could be useful in identifying ALSci quickly without adjusting for confounding factors. Further validation is required to evaluate it in larger groups and compare with ALS-specific cognitive screen.