SOLID BREAST NODULES - USE OF SONOGRAPHY TO DISTINGUISH BENIGN AND MALIGNANT LESIONS
SOLID BREAST NODULES - USE OF SONOGRAPHY TO DISTINGUISH BENIGN AND MALIGNANT LESIONS
复制标题
DOI：
10.1148/radiology.196.1.7784555
复制
发表时间：
1995-07-01
期刊：
影响因子：
19.7
通讯作者：
SISNEY, GA
中科院分区：
文献类型：
--
作者：
STAVROS, AT;THICKMAN, D;SISNEY, GA
目得：为了确定超声检查是否可以帮助准确区分良性固体乳腺结节从不确定或恶性结节，这种区别是否可以明确到足以使biopsiz.MATERIALS和METHODS：750超声固体乳腺结节被前瞻性地分为良性，不确定，或恶性。良性结节没有恶性特征，要么有强烈均匀的高回声，要么有一个椭圆形或少于四个柔和分叶的薄回声假包膜。超声分型与活检结果进行比较。的敏感性，特异性，阴性和阳性预测值的分类counted.Results：良性组织学特征被发现在625（83%）病变，恶性组织学特征，在125（17%）。在良性病变中，424例前瞻性分类为良性。两个被归类为良性病变被发现是恶性活检。因此，该分类方案的阴性预测值为99.5%。在125个恶性病变中，123个被正确分类为不确定或恶性（灵敏度为98.4%）。结论超声检查可以准确地将一些实体病变分类为良性，从而可以进行影像学随访而不是活检。
PURPOSE: To determine whether sonography could help accurately distinguish benign solid breast nodules from indeterminate or malignant nodules and whether this distinction could be definite enough to obviate biopsy.MATERIALS AND METHODS: Seven hundred fifty sonographically solid breast nodules were prospectively classified as benign, indeterminate, or malignant. Benign nodules had no malignant characteristics and had either intense homogeneous hyperechogenicity or a thin echogenic pseudocapsule with an ellipsoid shape or fewer than four gentle lobulations. Sonographic classifications were compared with biopsy results. The sensitivity, specificity, and negative and positive predictive values of the classifications were calculated.RESULTS: Benign histologic features were found in 625 (83%) lesions; malignant histologic features, in 125 (17%). Of benign lesions, 424 had been prospectively classified as benign. Two lesions classified as benign were found to be malignant at biopsy. Thus, the classification scheme had a negative predictive value of 99.5%. Of 125 malignant lesions, 123 were correctly classified as indeterminate or malignant (98.4% sensitivity).CONCLUSION Sonography can be used to accurately classify some solid lesions as benign, allowing imaging follow-up rather than biopsy.