HYPOTHALAMO-PITUITARY ADRENOCORTICAL FUNCTION IN RAT AFTER TREATMENT WITH BETAMETHASONE
HYPOTHALAMO-PITUITARY ADRENOCORTICAL FUNCTION IN RAT AFTER TREATMENT WITH BETAMETHASONE
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DOI：
10.1111/j.1476-5381.1976.tb07447.x
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发表时间：
1976-01-01
影响因子：
7.3
通讯作者：
HODGES, JR
中科院分区：
文献类型：
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作者：
BUCKINGHAM, JC;HODGES, JR
1倍他米松抑制大鼠下丘脑-垂体-肾上腺皮质（HPA）活动。2停药后HPA功能恢复正常。3.虽然促肾上腺皮质激素释放迅速恢复到其基础速率，但对应激的正常促肾上腺皮质激素反应的恢复延迟，并且正常的肾上腺皮质功能仅在血浆促肾上腺皮质激素达到“超正常”水平后才明显。4讨论了这些结果的生理意义和可能的临床意义。
1 Hypothalamo-pituitary-adrenocortical (HPA) activity was suppressed in rats treated with betamethasone. 2 Recovery of normal HPA function occurred after corticosteroid withdrawl. 3 Although corticotrophin release was rapidly restored to its basal rate there was a delay in the return of the normal adrenocorticotrophic response to stress and normal adrenocortical function was evident only after the plasma adrenocorticotrophic hormone had reached 'supra-normal' levels. 4 The physiological significance and possible clinical relevance of the results are discussed.