An Efficient Synthesis of Substituted Furans by Cupric Halide-Mediated Intramolecular Halocyclization of 2-(1-Alkyny1)-2-alken-1-ones
An Efficient Synthesis of Substituted Furans by Cupric Halide-Mediated Intramolecular Halocyclization of 2-(1-Alkyny1)-2-alken-1-ones
复制标题
卤化铜介导的 2-(1-Alkyny1)-2-alken-1-ones 分子内卤环化高效合成取代呋喃
DOI：
10.5012/bkcs.2013.34.3.887
复制
发表时间：
2013-03-20
影响因子：
1.7
通讯作者：
Xu, Chen
中科院分区：
文献类型：
--
作者：
Fu, Wei-jun;Xu, Feng-juan;Xu, Chen
研究了2-（1-炔基）-2-阿尔肯-1-酮与卤化铜分子内环化合成3-卤代呋喃的方法。在本方法中可以以中等至良好的产率获得宽范围的3-氯-和3-溴呋喃衍生物。3-卤代呋喃衍生物是潜在的合成中间体，用于扩增分子复杂性。
An efficient synthesis of 3-halofurans by the intramolecular cyclization of 2-(1-alkynyl)-2-alken-1-ones with cupric halide has been developed. A broad range of 3-chloro- and 3-bromofuran derivatives could be obtained in the present method in moderate to good yields. The 3-halofuran derivatives are potential synthetic intermediates for amplification of molecular complexity.