Nadir CA-125 concentration in the normal range as an independent prognostic factor for optimally treated advanced epithelial ovarian cancer
Nadir CA-125 concentration in the normal range as an independent prognostic factor for optimally treated advanced epithelial ovarian cancer
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DOI：
10.1093/annonc/mdm495
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发表时间：
2008-02-01
影响因子：
50.5
通讯作者：
Del Campo, J. M.
中科院分区：
文献类型：
--
作者：
Prat, A.;Parera, M.;Del Campo, J. M.
背景资料：手术后残留病灶的数量被认为是影响晚期上皮性卵巢癌（adEOC）患者生存的最重要因素。在接受最佳治疗的adEOC患者中，没有明确的预后因素[不包括国际妇产科联合会（FIGO）分期]。本回顾性研究的目的是分析的CA-125最低点完成后的最佳初级treatment.Patients和方法的预后价值：患者治疗的adEOC确定从1998年1月至2006年12月。入选标准：诊断时CA-125升高（>35 kU/l）; FIGO III-IV期，接受过最佳初级治疗（残留肿瘤）
Background: The amount of residual disease after surgery is considered the most important factor influencing the survival of patients with advanced epithelial ovarian cancer (adEOC). In optimally treated patients with adEOC, there are no well-established prognostic factors [excluding International Federation of Gynecology and Obstetrics (FIGO) stage]. The aim of this retrospective study is to analyze the prognostic value of the CA-125 nadir after the completion of an optimal primary treatment.Patients and methods: Patients treated for adEOC were identified from January 1998 to December 2006. Inclusion criteria: elevated CA-125 at time of diagnosis (>35 kU/l); FIGO stage III-IV treated with optimal primary treatment (residual tumor