Diabetes, hyperglycemia, and inflammation in older individuals - The health, aging and body composition study
Diabetes, hyperglycemia, and inflammation in older individuals - The health, aging and body composition study
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DOI：
10.2337/dc05-2327
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发表时间：
2006-08-01
期刊：
影响因子：
16.2
通讯作者：
Harris, Tamara B.
中科院分区：
文献类型：
--
作者：
De Rekeneire, Nathalie;Kritchevsky, Stephen B.;Harris, Tamara B.
目的：本研究的目的是评估老年人炎症与高血糖（空腹血糖受损[IFG]/糖耐量受损[IGT]）和糖尿病的关系。研究设计和方法——来自健康、衰老和身体组成研究的基线数据包括3075名功能良好的黑人和白人，年龄在70-79岁之间。结果：在参与者中，24%患有糖尿病，29%在基线时患有IFG/IGT。c反应蛋白（CRP）、白细胞介素-6 （IL-6）和肿瘤坏死因子- α (tnf - α)水平在糖尿病参与者和IFG/IGT患者中显著升高（P < 0.001）。在调整了年龄、性别、种族、吸烟、饮酒、教育和研究地点后，糖尿病参与者IL-6和tnf - α升高的几率分别为1-95 （95% CI 1.56-2.44）和1.88 (95% CI 1.51-2.35)， IFG/IGT参与者IL-6和tnf - α升高的几率分别为1.51（1.21-1.87）和1.14（0.92-1.42）。女性和男性CRP升高的比值比分别为2.90（2.13-3.95）和1.45 (1.03-2.04)，IFG/IGT患者的比值比分别为1.33（1.07-1.69）。在调整肥胖、脂肪分布和炎症相关条件后，IL-6仍与糖尿病和IFG/IGT显著相关。c反应蛋白和tnf -。分别与糖尿病显著相关，而IFG/IGT的风险估计值因肥胖调整而降低。在糖尿病参与者中，较高水平的HbA（1c）与所有三种炎症标志物的较高水平相关，但在完全调整后，只有CRP仍然显著。结论：我们的研究结果表明，血糖异常与炎症有关，尽管这种关系在糖尿病个体中是一致的，但也延伸到IFG/IGT患者。
OBJECTIVE - The objective of this study was to assess the association of inflammation with hyperglycemia (impaired fasting glucose [IFG]/impaired glucose tolerance [IGT] and diabetes in older individuals.RESEARCH DESIGN AND METHODS - Baseline data from the Health, Aging and Body Composition study included 3,075 well-functioning black and white participants, aged 70-79 years.RESULTS - Of the participants, 24% had diabetes and 29% had IFG/IGT at baseline. C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) levels (P < 0.001) were significantly higher among diabetic participants and those with IFG/IGT. Odds of elevated IL-6 and TNF-alpha (> 75th percentile) were, respectively, 1-95 (95% CI 1.56-2.44) and 1.88 (1.51-2.35) for diabetic participants and 1.51 (1.21-1.87) and 1.14 (0.92-1.42) for those with IFG/IGT after adjustment for age, sex, race, smoking, alcohol intake, education, and study site. Odds ratios for elevated CRP were 2.90 (2.13-3.95) and 1.45 (1.03-2.04) women and men and 1.33 (1.07-1.69) for those with IFG/IGT regardless of sex. After adjustment for obesity, fat distribution, and inflammation-related conditions, IL-6 remained significantly related to both diabetes and IFG/IGT. CRP in women and TNF-alpha. in both sexes were significantly related to diabetes, respectively, whereas risk estimates for IFG/IGT were decreased by adjustment for adiposity. Among diabetic participants, higher levels of HbA(1c) were associated with higher levels of all three markers of inflammation, but only CRP remained significant after full adjustment.CONCLUSIONS - Our findings show that dysglycemia is associated with inflammation, and this relationship, although consistent in diabetic individuals, also extends to those with IFG/IGT.