Emerging Roles of Downstream of Kinase 3 in Cell Signaling.
Emerging Roles of Downstream of Kinase 3 in Cell Signaling.
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DOI：
10.3389/fimmu.2020.566192
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发表时间：
2020
影响因子：
7.3
通讯作者：
Lam KP
中科院分区：
文献类型：
--
作者：
Loh JT;Teo JKH;Lim HH;Lam KP
激酶（Dok） 3的下游是Dok蛋白家族的一员，已知可调节各种免疫受体下游的信号通路。由于Dok-3缺乏内在的催化活性，它主要作为一种分子支架，以一种受调控的方式促进蛋白质复合物的成核，从而在指导信号级联反应中实现特异性。自发现以来，在确定Dok-3在限制B细胞受体信号传导中的作用方面取得了相当大的进展。尽管如此，Dok-3已经涉及toll样和c型凝集素受体的信号传导。新出现的数据进一步表明，在淋巴细胞和非淋巴细胞类型中，Dok-3可以作为激活剂和抑制剂，这表明Dok-3参与了大量的信号转导途径。在这篇综述中，我们将重点关注Dok-3的结构和表达谱，并强调其在B细胞、先天细胞以及骨和肺组织中的信号转导作用。
Downstream of kinase (Dok) 3 is a member of the Dok family of adaptor proteins known to regulate signaling pathways downstream of various immunoreceptors. As Dok-3 lacks intrinsic catalytic activity, it functions primarily as a molecular scaffold to facilitate the nucleation of protein complexes in a regulated manner and hence, achieve specificity in directing signaling cascades. Since its discovery, considerable progress has been made toward defining the role of Dok-3 in limiting B cell-receptor signaling. Nonetheless, Dok-3 has since been implicated in the signaling of Toll-like and C-type lectin receptors. Emerging data further demonstrate that Dok-3 can act both as an activator and inhibitor, in lymphoid and non-lymphoid cell types, suggesting Dok-3 involvement in a plethora of signal transduction pathways. In this review, we will focus on the structure and expression profile of Dok-3 and highlight its role during signal transduction in B cells, innate cells as well as in bone and lung tissues.