Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment.
Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment.
复制标题
DOI：
10.3233/jad-170865
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Salmon DP
中科院分区：
文献类型：
--
作者：
Zlatar ZZ;Muniz MC;Espinoza SG;Gratianne R;Gollan TH;Galasko D;Salmon DP
主观认知衰退(SCD)在老年人中很常见，可能是未来认知衰退的早期标志。研究表明，在非西班牙裔白人中，SCD与并发抑郁症状的关系比与客观认知表现更密切，但尚不清楚SCD、认知和抑郁的关联在西班牙裔老年人中是否表现出不同的表现。我们研究了社区卫生诊所转介的145名60岁或以上的西班牙裔个人的SCD是否与客观认知表现或抑郁症状有关，以筛选认知疾病。所有参与者都住在美墨边境附近，要么只会说西班牙语，要么会说西班牙语和英语的双语。纯记忆和全局认知成分是根据几项神经心理学测试的西班牙语版本的分数创建的。本组还完成了老年抑郁量表(GDS)和五项SCD问卷调查。多元回归分析表明，在调整了年龄、性别、教育程度和GDS得分后，SCD与记忆力或整体认知综合得分之间没有显著关联。相比之下，在调整了年龄、性别、教育程度、全球范围和记忆综合得分后，GDS和SCD之间存在显著的相关性。研究结果表明，SCD并不能准确地反映老年拉美裔美国人的认知状况，他们向初级保健医生提出了认知障碍。临床医生应根据有关抑郁症状的信息来解释这一人群中的SCD。需要对老年拉美裔进行纵向研究，以更好地描述这一人群中SCD的特征，并确定它是否可以预测未来的认知能力下降。
Subjective cognitive decline (SCD) is common in older adults and may be an early marker of future cognitive decline. Research suggest that SCD is more closely related to concurrent symptoms of depression than to objective cognitive performance in non-Hispanic Whites, but it is unknown whether the associations of SCD, cognition, and depression manifest differently in Hispanic older adults. We examined if SCD is associated with objective cognitive performance or with depression symptoms in 145 Hispanic individuals ages 60 or older referred by community health clinics for screening of cognitive complaints. All participants lived near the U.S.-Mexico border, spoke Spanish only, or were Spanish-English bilingual. Memory-only and global cognitive composites were created from scores on Spanish versions of several neuropsychological tests. The Geriatric Depression Scale (GDS) and a five-item SCD questionnaire developed by our group were also completed. Multiple regression analyses showed no significant associations between SCD and memory or global cognitive composite scores after adjusting for age, sex, education, and GDS score. In contrast, there was a significant association between GDS and SCD after adjusting for age, sex, education, global and memory composite scores. Findings suggest that SCD does not accurately reflect current cognitive status in older Hispanics who present to their primary care physician with cognitive complaints. Clinicians should interpret SCD in this population within the context of information about symptoms of depression. Longitudinal research is needed in older Hispanics to better characterize SCD in this population and to determine if it can predict future cognitive decline.