Induction of superovulation in prepubertal female rats by anterior pituitary transplants.
Induction of superovulation in prepubertal female rats by anterior pituitary transplants.
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通过垂体前叶移植诱导青春期前雌性大鼠超排卵。
DOI：
10.1530/jrf.0.0690265
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
S. Sasamoto
中科院分区：
文献类型：
--
作者：
K. Taya;T. Mizokawa;T. Matsui;S. Sasamoto
从成年正常或去势的雄性、20日龄或去卵巢的成年雌性供体(均含有大量FSH)移植26日龄大鼠的脑垂体前叶，于第29天早晨获得超数排卵。20日龄雄性和成年周期雌性的腺体移植不能提前第一次排卵时间，也不能诱导超数排卵。在可诱导超数排卵的大鼠中，受者移植后即刻血浆FSH显著升高，移植后至少12h仍维持较高水平。移植后54h，这些大鼠的促黄体生成素和卵泡刺激素也出现排卵前高峰。未诱导超数排卵的受者血浆FSH水平在72 h内未见明显升高。这些结果表明，超排卵泡的最终成熟是由移植的脑下垂体释放大量FSH引起的，而脑下垂体供体的性别与这一现象无关。
Transplants of 26-day-old rats of an anterior pituitary gland from adult intact or castrated male, 20-day-old or adult ovariectomized female donors (all of which contained large amounts of FSH) resulted in superovulation in recipients on the morning of Day 29. Transplants of the gland from 20-day-old males and adult cyclic females could not advance the time of first ovulation or induce superovulation. In the rats in which superovulation could be induced, a marked increase in plasma FSH was noted in recipients shortly after transplantation and the high levels of plasma FSH were maintained until at least 12 h after grafting. These rats also showed preovulatory surges of LH and FSH 54 h after grafting. No obvious elevation of plasma FSH was noted over 72 h in recipients in which superovulation could not be induced. These findings suggest that the final maturation of follicles for superovulation is induced by a transient release of a large amount of FSH from the grafted pituitary gland and that the sex of the pituitary donor has no bearing on this phenomenon.
高催乳素血症引起的性早熟：催乳素增强青春期前大鼠卵巢黄体酮对促性腺激素反应性的机制研究。
影响因子：
4.8
作者：
Advis,JP;Richards,JS;Ojeda,SR
通讯作者：
Ojeda,SR