Low heart rate variability is a risk factor for sudden cardiac death in type 2 diabetes
Low heart rate variability is a risk factor for sudden cardiac death in type 2 diabetes
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DOI：
10.1016/j.diabres.2003.10.009
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发表时间：
2004-04-01
影响因子：
5.1
通讯作者：
Kohno, N
中科院分区：
文献类型：
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作者：
Kataoka, M;Ito, C;Kohno, N
本研究的目的是检查心源性猝死（SCD）和心率变异性（HRV）之间的关系，在有和没有2型糖尿病的受试者，并确定是否低HRV可以预测SCD在2型糖尿病。受试者是8917名连续检查的人（3089名糖尿病患者和5828名非糖尿病患者），年龄35-69岁，他们接受了75 g口服葡萄糖耐量试验（OGTT）和心电图（ECG）。根据12导联ECG计算HRV，作为100个R-R间期的方差系数（CVR-R）。在5.2年的中位观察期内，56例受试者（33例糖尿病患者和23例非糖尿病患者）发生了SCD。在糖尿病受试者中，低CVR-R受试者的SCD死亡率往往较高（P = 0. 004）。校正年龄、性别、收缩压、总胆固醇（TC）、甘油三酯（TG）、BMI、缺血性ECG变化和吸烟史后，CVR-R的糖尿病受试者中SCD的相对风险（RR）为2.07（95%C1 1.02-4.17）。
The purpose of this study is to examine the association between sudden cardiac death (SCD) and heart rate variability (HRV) in subjects with and without type 2 diabetes and to determine whether low HRV can predict SCD in type 2 diabetes. Subjects were 8917 consecutively examined persons (3089 diabetic, and 5828 nondiabetic subjects) aged 35-69 years who underwent a 75 g oral glucose tolerance test (OGTT) together with electrocardiography (ECG). HRV was calculated from the 12-lead ECG as the coefficient of variance for 100 R-R intervals (CVR-R). During a median observation period of 5.2 years, SCD occurred in 56 subjects (33 diabetic, and 23 nondiabetic). Among diabetic subjects, mortality from SCD tended to be higher in subjects with a low CVR-R (P = 0.004). After adjustment for age, gender, systolic blood pressure, total cholesterol (TC), triglycerides (TG), BMI, ischemic ECG change, and smoking history, relative risk (RR) of SCD was 2.07 (95% C1 1.02-4.17) in diabetic subjects with a CVR-R