Biodistribution of fluoresceinated dextran using novel nanoparticles evading reticuloendothelial system
Biodistribution of fluoresceinated dextran using novel nanoparticles evading reticuloendothelial system
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DOI：
10.1016/s0378-5173(99)00447-0
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发表时间：
2000-07-20
影响因子：
5.8
通讯作者：
Ghosh, PK
中科院分区：
文献类型：
--
作者：
Gaur, U;Sahoo, SK;Ghosh, PK
迄今为止，通过减小颗粒尺寸以及用泊洛沙姆和泊洛沙胺使颗粒表面具有亲水性，可以克服循环纳米颗粒从血流中快速清除以及它们被肝脏和脾脏高摄取的问题。我们制备了直径小于100 nm、具有精确尺寸分布的聚乙烯吡咯烷酮水凝胶纳米颗粒。由于这些颗粒的内核也是亲水性的，因此这些颗粒能够封装水溶性化合物。这些颗粒的生物分布显示，肝脏和脾脏中巨噬细胞的吸收几乎可以忽略不计（< 1%），并且类似于这些颗粒的 5-10% 即使在静脉注射后 8 小时仍保留在循环中。注射。随着颗粒尺寸的增加表面疏水性可以增加这些颗粒的RES吸收。由于在血液中停留时间较长，水凝胶纳米颗粒具有潜在的治疗应用，特别是在癌症方面：封装在这些颗粒中的水溶性细胞毒性剂可以靶向肿瘤，同时最大限度地减少对网状内皮系统（RES）的毒性可能性。 (C) 2000 Elsevier Science B.V. 保留所有权利。
The rapid clearance of circulating nanoparticles from the blood stream coupled with their high uptake by liver and spleen has thus far been overcome by reducing the particle size, and by making the particle surface hydrophilic with poloxamers and poloxamines. We have prepared hydrogel nanoparticles of polyvinylpyrrolidone of a size less than 100 nm diameter with precise size distribution. Since the inner cores of these particles are also hydrophilic, these particles are capable of encapsulating water-soluble compounds. Biodistribution of these particles shows practically negligible (< 1%) uptake by the macrophages in liver and spleen, and similar to 5-10% of these particles remain in circulation even 8 h after i.v. injection. increasing the surface hydrophobicity as wt ll as particle size can increase the RES uptake of these particles. Because of longer residence in blood, the hydrogel nanoparticles have potential therapeutic applications particularly in cancer: the water-soluble cytotoxic agents encapsulated in these particles call be targeted to tumors while minimizing the likelihood of toxicity to reticuloendothelial system (RES). (C) 2000 Elsevier Science B.V. All rights reserved.