THE ANATOMY, ULTRASTRUCTURE AND FLUID-DYNAMICS OF THE DEVELOPING VASCULATURE OF THE EMBRYONIC CHICK WING BUD
THE ANATOMY, ULTRASTRUCTURE AND FLUID-DYNAMICS OF THE DEVELOPING VASCULATURE OF THE EMBRYONIC CHICK WING BUD
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DOI：
10.1016/0045-6039(85)90603-7
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发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
CAPLAN, AI
中科院分区：
文献类型：
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作者：
DRUSHEL, RF;PECHAK, DG;CAPLAN, AI
在Hamburger-Hamilton阶段20-25，详细描述了鸡胚翼芽和周围肩、腹、腹区域血管模式发育的时空顺序。用非反应性水示踪剂（苯胺蓝）微注射血管，主要交通模式可见。广泛无血管区域的形成和软骨表型的出现与血管系统从翼核的撤退有关。血管细胞的超微结构研究表明，血管在成体血管模式形成后，直到25期仍保持单层且未分化。血管细胞分化只发生在肱动脉细胞中，直到35期，静脉和毛细血管仍保持早期形态。这种血管模式可能是反映或指导肢体模式发展的重要组成部分。
The spatiotemporal sequence of vascular pattern development in the embryonic chick wing bud and surrounding shoulder, flank and belly regions is detailed for Hamburger-Hamilton stages 20-25. Vasculature was microinjected with an unreactive aqueous tracer (aniline blue), and major traffic patterns were visualized. Formation of extensive avascular regions and the emergence of chondrogenic phenotypes are correlated with the retreat of the vasculature from the wing core. Ultrastructural studies of vascular cells show that vessels remain monolayered and undifferentiated until stage 25, after the adult vascular pattern was laid down. Vascular cytodifferentiation occurs only in the cells of the brachial artery until stage 35, with the veins and capillaries retaining an early morphology. This vascular pattern may be an important component reflecting or directing limb pattern development.