Viruses and microRNAs
Viruses and microRNAs
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DOI：
10.1038/ng1793
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发表时间：
2006-06-01
期刊：
影响因子：
30.8
通讯作者：
Cullen, Bryan R.
中科院分区：
文献类型：
--
作者：
Cullen, Bryan R.
RNA干扰和细胞microRNA（miRNAs）的发现不仅影响了生物学研究的进行，而且揭示了转录后基因调控的全新水平。在这里，我讨论了最近在几种致病性人类病毒中发现的病毒编码的miRNA的潜在功能，并提出细胞miRNA可能对病毒进化产生了重大影响，并可能继续影响病毒的体内组织嗜性。我们对病毒编码的miRNAs的作用和重要性的了解越来越多，这可能会为建立潜伏感染的病毒（如疱疹病毒）如何避免被宿主先天性或适应性免疫系统消除提供新的见解。对病毒miRNA功能的研究也可能为治疗某些病毒引起的疾病提供新的方法。
The discovery of RNA interference and cellular microRNAs (miRNAs) has not only affected how biological research is conducted but also revealed an entirely new level of post-transcriptional gene regulation. Here, I discuss the potential functions of the virally encoded miRNAs recently identified in several pathogenic human viruses and propose that cellular miRNAs may have had a substantial effect on viral evolution and may continue to influence the in vivo tissue tropism of viruses. Our increasing knowledge of the role and importance of virally encoded miRNAs will probably offer new insights into how viruses that establish latent infections, such as herpesviruses, avoid elimination by the host innate or adaptive immune system. Research into viral miRNA function might also suggest new approaches for treating some virally induced diseases.