Dealing with Danger in the CNS: The Response of the Immune System to Injury.
Dealing with Danger in the CNS: The Response of the Immune System to Injury.
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DOI：
10.1016/j.neuron.2015.05.019
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发表时间：
2015-07-01
期刊：
影响因子：
16.2
通讯作者：
Kipnis J
中科院分区：
文献类型：
--
作者：
Gadani SP;Walsh JT;Lukens JR;Kipnis J
对抗病原体和维持组织内稳态是生存的先决条件。这两种功能都由免疫系统维持，尽管后者在CNS的背景下经常被忽视。免疫细胞在中枢神经系统中的单纯存在长期以来被认为是病理学的标志，但最近的研究表明，免疫信号可以赋予受损的中枢神经系统关键的神经保护作用，这一观点受到了挑战。在这篇综述中，我们描述了免疫事件的时间顺序，中枢神经系统损伤。从损伤部位的立即变化开始，包括神经细胞的死亡和损伤相关分子模式（DAMP）的释放，并通过先天性和适应性免疫反应进行，我们描述了炎症介质的级联反应及其损伤后效应的影响。最后，我们提出了一个修订后的解释免疫特权在大脑中，考虑到有益的神经免疫通信。
Fighting pathogens and maintaining tissue homeostasis are prerequisites for survival. Both of these functions are upheld by the immune system, though the latter is often overlooked in the context of the CNS. The mere presence of immune cells in the CNS was long considered a hallmark of pathology, but this view has been recently challenged by studies demonstrating that immunological signaling can confer pivotal neuroprotective effects on the injured CNS. In this review we describe the temporal sequence of immunological events that follow CNS injury. Beginning with immediate changes at the injury site including death of neural cells and release of damage-associated molecular patterns (DAMPs), and progressing through innate and adaptive immune responses, we describe the cascade of inflammatory mediators and the implications of their post-injury effects. We conclude by proposing a revised interpretation of immune privilege in the brain, which takes beneficial neuro-immune communications into account.
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DOI：
10.1073/pnas.0812690106
发表时间：
2009-06-02
影响因子：
11.1
作者：
Cayrol, Corinne;Girard, Jean-Philippe
通讯作者：
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影响因子：
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作者：
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影响因子：
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影响因子：
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影响因子：
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作者：
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