Prenylated Indole Diterpene Alkaloids from a Mine-Soil-Derived Tolypocladium sp.
Prenylated Indole Diterpene Alkaloids from a Mine-Soil-Derived Tolypocladium sp.
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来自矿土衍生的 Tolypocladium sp 的异戊二烯化吲哚二萜生物碱。
DOI：
10.1021/acs.jnatprod.8b00589
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发表时间：
2019-02-01
影响因子：
5.1
通讯作者：
Yang, Xiao-Long
中科院分区：
文献类型：
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作者：
Xu, Lu-Lin;Hai, Ping;Yang, Xiao-Long
从一种来源于矿山土壤的真菌Tolypocladium sp. XL 115中分离得到10个新的异戊烯化吲哚二萜生物碱tolypocladin A-J（1-10），包括4个氯代代谢产物。1-10的结构和绝对构型通过光谱分析、ECD计算和与已知化合物的比较确定。化合物1和8显示出明显的抗菌活性。此外，化合物1还显示出对所有测试的人癌细胞系的弱细胞毒活性，并抑制患者来源的HCC细胞T1224的生长和活力。
Ten new prenylated indole diterpene alkaloids, tolypocladin A-J (1-10), including four chlorinated metabolites, have been isolated from a culture of a mine-soil-derived fungus, Tolypocladium sp. XL115. The structures and absolute configurations of 1-10 were determined by spectroscopic analysis, ECD calculations, and comparison with known compounds. Compounds 1 and 8 displayed significant antimicrobial activities. In addition, compound 1 also showed weak cytotoxic activity against all tested human cancer cell lines and suppressed the growth and viability of the patient-derived HCC cells T1224.