Temporal specificity in the cortical plasticity of visual space representation
Temporal specificity in the cortical plasticity of visual space representation
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DOI：
10.1126/science.1070521
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发表时间：
2002-06-14
期刊：
影响因子：
56.9
通讯作者：
Dan, Y
中科院分区：
文献类型：
--
作者：
Fu, YX;Djupsund, K;Dan, Y
哺乳动物视皮层的电路和功能是由视觉刺激的模式塑造的，这种可塑性可能是由突触修饰介导的。在成年猫中，两个相邻视网膜区域的异步视觉刺激以高精度控制两组皮层神经元的相对发放时间。这种异步配对诱导皮层内连接的快速修改和感受野的变化。这些变化取决于时间顺序和视觉刺激之间的间隔与尖峰时间依赖性突触可塑性的方式一致。与在猫身上发现的皮层变化平行，这种异步视觉刺激也会引起人类空间感知的变化。
The circuitry and function of mammalian visual cortex are shaped by patterns of visual stimuli, a plasticity likely mediated by synaptic modifications. In the adult cat, asynchronous visual stimuli in two adjacent retinal regions controlled the relative spike timing of two groups of cortical neurons with high precision. This asynchronous pairing induced rapid modifications of intracortical connections and shifts in receptive fields. These changes depended on the temporal order and interval between visual stimuli in a manner consistent with spike timing-dependent synaptic plasticity. Parallel to the cortical modifications found in the cat, such asynchronous visual stimuli also induced shifts in human spatial perception.