Microsporum canis infection mimics pemphigus erythematosus.
Microsporum canis infection mimics pemphigus erythematosus.
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DOI：
10.4103/0019-5154.110866
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发表时间：
2013-05
影响因子：
1.7
通讯作者：
Ishikawa O
中科院分区：
文献类型：
--
作者：
Amano H;Kishi C;Yokoyama Y;Shimizu A;Anzawa K;Mochizuki T;Ishikawa O
我们报告一位55岁的日本女性，脸部及颈部有两个月的多发性红斑及糜烂病史。根据临床表现，我们初步诊断她患有红斑性天疱疮。然而，组织病理学检查和直接免疫荧光研究的结果并不支持初步诊断。此外，抗桥粒芯糖蛋白1和3抗体均为阴性。随后，对鳞片进行显微镜检查，发现丝状真菌，真菌培养物对大分生孢子呈阴性。利用分子生物学技术，我们确定了真菌为犬小孢子菌，它会导致人畜共患感染。免疫反应的真菌可能是激烈的，因此，出疹有时显示不典型的临床表现。
We report a 55-year-old Japanese woman with a two-month history of multiple pruritic erythema and erosion on her face and neck. Based on the clinical appearance, we initially diagnosed her as having pemphigus erythematosus. However, the results of a histopathological examination and a direct immunofluorescence study did not support the initial diagnosis. Additionally, anti-desmoglein 1 and 3 antibodies were all negative. Subsequently, a microscopic examination of scales revealed filaments of fungi and a fungal culture was negative for macroconidium. Using molecular biology techniques, we identified the fungus as Microsporum canis, which causes a zoonotic infection. The immune reaction to the fungi could be drastic and therefore, the eruption sometimes displays atypical clinical manifestations.