Emerging fungal infections in immunocompromised patients.
Emerging fungal infections in immunocompromised patients.
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DOI：
10.3410/m3-14
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Rotstein C
中科院分区：
文献类型：
--
作者：
Low CY;Rotstein C
侵袭性真菌感染是重要的感染，并且在免疫功能低下的宿主（例如已经进行造血干细胞和实体器官移植的患者）中发病率增加。尽管我们扩大了抗真菌药物，这些感染引起相当大的发病率和死亡率。事实上，在这些侵袭性真菌感染中已经出现了某些趋势：侵袭性霉菌感染的发病率上升，念珠菌属的非白念珠菌菌株增加，导致侵入性疾病，最后，由于这些药剂的过度使用，出现对广谱抗真菌剂具有抗性的较不敏感的真菌菌株。临床医生必须认识到这些侵袭性真菌感染的潜在风险的患者群体，以及这些感染的风险因素。通过使用更敏感的基于非培养的诊断技术，可以更早地开始适当的治疗，以提高这些免疫功能低下患者群体的生存率。
Invasive fungal infections are infections of importance and are increasing in incidence in immunocompromised hosts such as patients who have had hematopoietic stem cell and solid organ transplants. Despite our expanded antifungal armamentarium, these infections cause considerable morbidity and mortality. Indeed, certain trends have emerged in these invasive fungal infections: a rise in the incidence of invasive mold infections, an increase in the non-albicans strains of Candida spp. causing invasive disease and, finally, the emergence of less susceptible fungal strains that are resistant to the broader-spectrum antifungal agents due to overutilization of these agents. Clinicians must recognize the patient groups that are potentially at risk for these invasive fungal infections, as well as the risk factors for such infections. By using more sensitive nonculture-based diagnostic techniques, appropriate therapy may be initiated earlier to enhance survival in these immunocompromised patient populations.